Bone marrow-derived mesenchymal stem cells laden novel thermo-sensitive hydrogel for the management of severe skin wound healing

Materials Science & Engineering. C, Materials for Biological Applications
Zhang LeiZhang Lin

Abstract

Bone marrow-derived mesenchymal stem cells (BMSCs) are easy to collect and culture, and it is identified that it has multi-directional differentiation potential, moreover it has low immunogenicity, hence it can be used as an allogeneic cell source for skin wound healing. Hydrogel has been widely used in skin wound healing own to it is able to mimic the 3D microenvironment of cells, which supports cell proliferation, migration and secretion. In this study, we created a novel biocompatible thermo-sensitive hydrogel to carry BMSCs for full-thickness skin wound healing. The thermo-sensitive hydrogel loaded with BMSCs can fast achieve sol-gel transition after implanting to the wound. Histological results confirmed that hydrogel-BMSCs combination group showed significant promotion of wound closure, epithelial cells' proliferation and re-epithelialization, and reduced inflammatory responses in the wounds and in the tissues surrounding the wounds. The combination therapy also can promote collagen deposition, TGF-β1 and bFGF secretion and tissue remodeling. The present study provides a promising strategy for the clinical treatment of skin wounds.

Citations

Mar 2, 2019·Annual Review of Biomedical Engineering·Lucília P da SilvaAlexandra P Marques
Apr 28, 2020·Advanced Healthcare Materials·Xin ZhengDavid L Kaplan
Mar 17, 2019·Stem Cell Research & Therapy·Anastasia ShpichkaPeter Timashev
Sep 5, 2020·Drug Design, Development and Therapy·Abd Kakhar UmarNasrul Wathoni
Nov 6, 2020·Growth Factors·Sanam DolatiSeyed Kazem Shakouri
Jan 31, 2020·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Haiqin HuangZhenghong Wu
Mar 8, 2021·Drug Delivery and Translational Research·Hamid Reza AghayanBabak Arjmand
Aug 8, 2021·Cells·Raquel Guillamat-Prats
Aug 11, 2021·ACS Nano·Yongping LiangBaolin Guo
Mar 14, 2021·Archivum Immunologiae Et Therapiae Experimentalis·Wen-Yan TangXue-Qun Luo
Jan 21, 2022·Journal of Materials Science. Materials in Medicine·Ying LiuYongli Bao

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