Bone marrow-derived mesenchymal stem cells suppress NK cell recruitment and activation in PolyI:C-induced liver injury

Biochemical and Biophysical Research Communications
Mengmeng QuChangyong Li

Abstract

Mesenchymal stem cells (MSCs) have been shown to have an immunomodulatory capability and clinical potential in immune diseases. However, it is unknown how MSCs may affect immunity in liver injury. This study was designed to explore the effect of bone marrow-derived MSCs (BM-MSCs) on hepatic natural killer (NK) cells in polyinosinic-polycytidylic acid (PolyI:C)-induced liver injury. Unlike in controls, adoptive transfer of BM-MSCs in mice ameliorated PolyI:C-induced liver injury, as shown by lower alanine aminotransferase levels and decreased lymphocyte infiltration in the liver. Importantly, BM-MSCs suppress NK cell accumulation and activation in the liver, which plays an important role in PolyI:C-induced liver injury. Furthermore, NK cells co-cultured with BM-MSCs reduced expression of sphingosine-1-phosphate receptor type 5 (S1PR5), an important receptor required for NK cell trafficking in vivo. BM-MSC administration suppressed the elevation of expression of S1PR5 in the liver induced by PolyI:C injection. Accordingly, BM-MSCs inhibited the chemotactic activity of NK cells induced by sphingosine-1-phosphate (S1P, the ligand of S1PR5). Our results provide an additional mechanism for the immunosuppressive effect of BM-MSCs on N...Continue Reading

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Citations

Mar 20, 2016·Biochemical and Biophysical Research Communications·Jisun LimDong-Myung Shin
Nov 16, 2019·Cell Proliferation·Wei Jiang, Jianyong Xu
Feb 20, 2017·Cellular and Molecular Life Sciences : CMLS·Na Li, Jinlian Hua
Jan 6, 2016·Biomedicines·Clara NicolasScott L Nyberg
Sep 7, 2020·Journal of Cellular Physiology·Milad MoloudizargariMohammad Abdollahi
Oct 14, 2020·Stem Cells and Development·Zhihua RenRiyi Shi
Feb 27, 2021·Therapeutic Advances in Chronic Disease·Chengmei HeFengchun Zhang

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