Bone marrow-derived stem cells preserve cone vision in retinitis pigmentosa

The Journal of Clinical Investigation
Lois E H Smith

Abstract

Retinitis pigmentosa is a heritable group of blinding diseases resulting from loss of photoreceptors, primarily rods and secondarily cones, that mediate central vision. Loss of retinal vasculature is a presumed metabolic consequence of photoreceptor degeneration. A new study shows that autologous bone marrow-derived lineage-negative hematopoietic stem cells, which incorporate into the degenerating blood vessels in two murine models of retinitis pigmentosa, rd1 and rd10, prevent cone loss. The use of autologous bone marrow might avoid problems with rejection while preserving central cone vision in a wide variety of genetically disparate retinal degenerative diseases.

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Citations

Apr 11, 2013·Investigative Ophthalmology & Visual Science·Sergio CaballeroMaria B Grant
Aug 21, 2014·International Journal of Molecular Sciences·Yuxi HeGuanfang Su
Jul 13, 2012·Seminars in Ophthalmology·Medi EslaniSajjad Ahmad
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Aug 5, 2016·Asia-Pacific Journal of Ophthalmology·Qingjiong Zhang
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Oct 18, 2020·Antioxidants·Paolo Giuseppe LimoliMarcella Nebbioso
Jun 29, 2021·Clinical Ophthalmology·Marcella NebbiosoAntonella Polimeni

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Methods Mentioned

BETA
transfection

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