Bone Marrow Edema in the Knee and Its Influence on Clinical Outcome After Matrix-Based Autologous Chondrocyte Implantation: Results After 3-Year Follow-up

The American Journal of Sports Medicine
Thomas R NiethammerPeter E Müller

Abstract

Third-generation autologous chondrocyte implantation (ACI) is an established method for treatment of full-thickness cartilage defects in the knee joint. Subchondral bone marrow edema (BME) is frequently observed after ACI, with unknown pathogenesis and clinical relevance. To investigate the occurrence and clinical relevance of BME after third-generation ACI in the knee joint during the postoperative course of 36 months. Cohort study; Level of evidence, 3. A total of 38 circumscribed full-thickness cartilage defects in 30 patients were included in this study. All defects were treated with third-generation ACI (Novocart 3D). A standardized MRI examination was carried out after 1.5, 3, 6, 12, 24, and 36 months. Bone marrow edema was observed in 78.9% of defects over the postoperative course, with initial occurrence in the first 12 months. The size of the BMEs were determined according to their maximum diameter and were classified as small (<1 cm), medium (<2 cm), large (<4 cm), and very large (diffuse; >4 cm). Clinical outcomes in patients were analyzed by use of the International Knee Documentation Committee (IKDC) scoring system and a visual analog scale for pain. There were 5.3% (n=2) small, 28.9% (n=11) medium, 34.2% (n=13) la...Continue Reading

References

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Jul 11, 2013·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Thomas R NiethammerMatthias F Pietschmann
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Citations

Apr 15, 2016·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Elizaveta KonNogah Shabshin
May 8, 2015·International Orthopaedics·Thomas R NiethammerPeter Müller
May 4, 2017·EFORT Open Reviews·Maurilio MarcacciGiuseppe Filardo
Mar 19, 2019·Cartilage·Juan Manuel López-AlcorochoPedro Guillén-García
May 15, 2019·The American Journal of Sports Medicine·Kristofer J JonesPeter D Fabricant
Dec 2, 2020·The Journal of Knee Surgery·Jacob G CalceiJack Farr
Dec 4, 2020·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Edna IordacheMichael T Hirschmann
May 9, 2021·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Hailey P HuddlestonAdam B Yanke

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Software Mentioned

Power
Syngo
Novocart
SPSS

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Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA
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