Bone marrow granuloma in typhoid Fever: a morphological approach and literature review

Case Reports in Infectious Diseases
Kavitha MunirajReba Kanungo

Abstract

Typhoid fever is one of the few bacterial infections in humans where bone marrow evaluation is routinely recommended. However, the morphological aspect of typhoid fever in bone marrow has been rarely described in the literature. We describe a 25-year-old male patient who presented with prolonged fever suspected to be of tubercular etiology. Bone marrow examination showed well-formed histiocytic and epithelioid granulomas and erythrophagocytosis; and the bone marrow aspirate culture grew Salmonella typhi A. In view of potential clinical implications, typhoid fever should be considered as a differential diagnosis to tuberculosis in the evaluation of prolonged fever; especially in high prevalent areas. We suggest that erythrophagocytosis may serve as a morphological marker in typhoid granulomas in the bone marrow; and bone marrow culture should be submitted in every suspected case for appropriate patient management.

References

Mar 21, 2002·Journal of Pediatric Hematology/oncology·V S SakhalkarS T Miller
Jun 23, 2004·Internal Medicine·Ali MertYildirim Aktuglu
Dec 19, 2007·PLoS Pathogens·Rebecca N NixCorrella S Detweiler
Dec 21, 2007·The Korean journal of laboratory medicine·Hee-Jung ChungChan-Jeoung Park
Apr 8, 2009·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·S BharadwajA Aldahham

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BETA
biopsy
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