PMID: 8603000Feb 1, 1996Paper

Bone marrow histology and CD34 immunostaining in the prognostic evaluation of primary myelodysplastic syndromes

British Journal of Haematology
A OrianiG Lambertenghi Deliliers

Abstract

The prognostic impact of bone marrow biopsy (BMB) histology and CD34 immunoreactivity was compared with that of the more conventional parameters (the FAB diagnosis, peripheral blood values, percentage of BM blasts and some common prognostic scores) in 100 MDS patients. Statistical correlations among the cytological, haematological, histological and immunohistochemical parameters and their relationship with clinical outcome were searched for. At univariate analysis, FAB classification (P < 0.001), pattern of blastic infiltration at BMB (P < 0.005), presence of CD34+ aggregates (P < 0.0005), percentage of blasts in BM aspirate (P < 0.0001) and percentage of CD34 positivity (P < 0.0001) proved to be linked to leukaemic transformation and, except for FAB classification, retained a high degree of prognostic significance in terms of survival. Leukaemic transformation occurred in 16/18 patients simultaneously presenting 'large' blastic infiltrates at BMB and CD34+ aggregates (P < 0.00001); 9/17 evaluable patients died within 12 months of diagnosis (P < 0.001)> Discriminant functions for leukaemic transformation and survival did not offer any advantage over univariate analysis in the prognostic work-up. The results indicate that the si...Continue Reading

Citations

Jan 1, 2009·Current Hematologic Malignancy Reports·Ahrin Koppel, Gary Schiller
Dec 8, 2010·Current Hematologic Malignancy Reports·Fabio P S SantosFarhad Ravandi
Aug 19, 2008·Current Oncology Reports·Ahrin Koppel, Gary Schiller
Jan 16, 2003·Leukemia Research·David P Steensma, Ayalew Tefferi
Sep 21, 2000·British Journal of Haematology·K ShimazakiM Kikuchi
Jul 3, 2013·Archives of Pathology & Laboratory Medicine·Kristin E HuntKathryn Foucar
Mar 28, 1998·Leukemia & Lymphoma·G Lambertenghi DeliliersA Oriani
Nov 8, 2011·Hematology/oncology Clinics of North America·Sa A Wang
Dec 1, 2010·Surgical Pathology Clinics·Sa A Wang
Jul 3, 2007·Leukemia Research·Hans-Peter HornyPeter Valent
Mar 29, 2008·International Journal of Laboratory Hematology·H J HuhJ W Huh
Apr 17, 2008·Hematological Oncology·Kiyoyuki Ogata
Sep 27, 2005·Leukemia Research·Richard D IronsHua Fu
Jan 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E VerburghG Verhoef
Dec 24, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matteo Giovanni Della PortaMario Cazzola
May 10, 2002·Leukemia & Lymphoma·K ShimazakiM Kikuchi
Dec 24, 2018·Seminars in Hematology·Aaron HodesRaul Braylan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.