PMID: 6414077Oct 1, 1983Paper

Bone marrow histology in Waldenström's macroglobulinaemia. Clinical relevance of subtype recognition

Scandinavian Journal of Haematology
R BartlG Hoffmann-Fezer

Abstract

Bone marrow biopsies of 137 patients with Waldenström's macroglobulinaemia (WM), 26 with non-secretory immunocytoma and 32 with benign monoclonal gammopathy were processed for histologic evaluation. Bone marrow involvement was found in 110 (80%) initially, and in 24 (18%) in sequential biopsies. 3 types were distinguished: lymphoplasmacytoid (47%), lymphoplasmacytic (42%) and polymorphous (11%) with median survivals of 74, 25 and 12 months, respectively. When grouped according to the tumour cell mass in the biopsies, the median survivals were 55, 21 and 8 months for less than 20 vol%, 20-50 vol% and greater than 50 vol% respectively; in each subtype, the tumour cell mass correlated with the disease progression. 6 clinical variables were also found prognostically significant. These results demonstrate that (i) 98% of patients with WM have bone marrow involvement; (ii) the lymph node sub-classification is applicable to the bone marrow and has both clinical and prognostic significance; (iii) patients may be staged according to the tumour cell burden in the bone marrow biopsy.

References

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Citations

Jan 1, 1987·Journal of Clinical Apheresis·P JacobsH S King
Aug 29, 2000·Hematological Oncology·R G OwenG J Morgan
Aug 4, 2007·British Journal of Haematology·Rafael Fonseca, Suzanne Hayman
Feb 18, 2009·British Journal of Haematology·Xavier LeleuSteven P Treon
Apr 26, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mihai MerzianuCarlos E Bueso-Ramos
Feb 21, 2006·British Journal of Haematology·S A JohnsonUNKNOWN Haemato-Oncology Task Force of the British Committee for Standards in Haematology
Jan 7, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M A DimopoulosM Dalakas
Nov 25, 2004·Hematology·Morie A GertzSteven P Treon
Oct 8, 2005·Advances in Anatomic Pathology·Pei Lin, L Jeffrey Medeiros
Dec 14, 2011·Advances in Anatomic Pathology·Saad P ShaheenL Jeffrey Medeiros
Feb 13, 2001·European Journal of Haematology·E C HatzimichaelK L Bourantas
Apr 30, 2004·Current Treatment Options in Oncology·Irene M Ghobrial, Thomas E Witzig
Jan 1, 1988·Critical Reviews in Oncology/hematology·R A Kyle, P A Greipp
Jan 8, 2000·Hematology/oncology Clinics of North America·M A DimopoulosC Matsouka

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