Bone Marrow Homing and Engraftment Defects of Human Hematopoietic Stem and Progenitor Cells

Mediterranean Journal of Hematology and Infectious Diseases
Giovanni CaocciGiorgio La Nasa

Abstract

Homing of hematopoietic stem cells (HSC) to their microenvironment niches in the bone marrow is a complex process with a critical role in repopulation of the bone marrow after transplantation. This active process allows for migration of HSC from peripheral blood and their successful anchoring in bone marrow before proliferation. The process of engraftment starts with the onset of proliferation and must, therefore, be functionally dissociated from the former process. In this overview, we analyze the characteristics of stem cells (SCs) with particular emphasis on their plasticity and ability to find their way home to the bone marrow. We also address the problem of graft failure which remains a significant contributor to morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). Within this context, we discuss non-malignant and malignant hematological disorders treated with reduced-intensity conditioning regimens or grafts from human leukocyte antigen (HLA)-mismatched donors.

Citations

Feb 13, 2018·Advanced Materials·Megan E CookeLiam M Grover
Aug 23, 2018·Molecular Biology of the Cell·Chelsea A Saito-ReisJennifer M Gillette
Jan 20, 2019·Cells·Alicja M GruszkaMyriam Alcalay
Feb 1, 2020·Tissue Engineering and Regenerative Medicine·Eunjin LeeJung-Woog Shin
Aug 6, 2020·Frontiers in Cell and Developmental Biology·Victoria D BaliseJennifer M Gillette
Mar 23, 2021·Journal of Theoretical Biology·Salvador ChuliánMaría Rosa
May 13, 2021·Health Science Reports·Mohammad RafieeMohammad Hossein Mohammadi

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Methods Mentioned

BETA
GTPase
ubiquitination

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