Bone marrow infarction due to acute graft-versus-host disease in an acute lymphoblastic leukemia patient after unrelated bone marrow transplantation

Bone Marrow Transplantation
A MoriM Asaka

Abstract

We report a case of bone marrow infarction in a 20-year-old woman with acute lymphocytic leukemia (ALL) who underwent unrelated bone marrow transplantation (BMT). Hematopoietic engraftment occurred on day 9 and, thereafter, the patient developed acute dermal and hepatic graft-versus-host disease (GVHD). She also experienced severe arthralgia in her knee joints on day 21. Immunosuppressive therapy with prednisolone (PSL) for acute GVHD was given, and the arthralgia improved rapidly, correlating with the improvement in dermal and hepatic GVHD. Based on the laboratory findings and analysis of magnetic resonance images, she was diagnosed as having bone marrow infarction. The cause of the bone marrow infarction was thought to be acute GVHD-related microangiopathy.

Citations

Jan 29, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sophie PaczesnyJames L M Ferrara
Apr 26, 2006·Transplant Immunology·Shosaku NomuraKunio Hayashi
Feb 2, 2006·The Journal of Antimicrobial Chemotherapy·C CharlierO Lortholary
Aug 20, 2019·International Journal of Laboratory Hematology·Anne Deucher, Geoffrey D Wool

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