Bone marrow investigation with technetium-99m microcolloid and magnetic resonance imaging in patients with malignant myelolympho-proliferative diseases

European Journal of Nuclear Medicine
A WiddingH Schicha

Abstract

In 63 patients with primary extramedullary malignant lymphoma or plasmacytoma, a study was performed in order to evaluate bone marrow involvement. All patients underwent a 99mTc microcolloid bone marrow whole body imaging (scintigraphy), using a gamma camera interfaced with a computer, followed by nuclear magnetic resonance bone marrow imaging (MRI), (1.5 Tesla). MR images were made of the lumbosacral region, the pelvic region, both femoral and other parts of the skeleton, according to focal lesions in the scintigraphy. A posterior iliac crest bone marrow biopsy was used as a standard reference. In the present study, both scintigraphy and MRI showed a dissiminated or focal involvement or a combination of both. In 53 of the 63 patients (84%) the results were in accordance. Pathological MR signals or pathological findings in scintigraphy did not always correspond to tumorous bone marrow involvement, and were shown to reflect reactive changes in the central part of the skeleton in combination with a periphery radionuclide extention interpreted as a periphery compensatory hematopoietic proliferation. The negative predictive value of scintigraphy and MRI was 92% and 100%, respectively. When combining the results of both examinations...Continue Reading

Citations

Jan 1, 1991·European Journal of Nuclear Medicine·S N Reske
Feb 7, 2001·Radiographics : a Review Publication of the Radiological Society of North America, Inc·A GuermaziJ Frija
Nov 13, 2003·Journal of Biomedical Materials Research. Part a·Yoon Jeong ParkSeung Jin Lee
Feb 1, 1997·Clinical Nuclear Medicine·B AgrenP Aspelin
Nov 19, 2003·Journal of Biomedical Materials Research. Part a·Kazuhiro Tanahashi, Antonios G Mikos
Apr 1, 1997·Seminars in Nuclear Medicine·A Z KrasnowA T Isitman

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