Abstract
Besides peripheral cytopenias, bone marrow abnormalities, such as fibrosis, pure red cell aplasia and aplastic anemia have been reported in patients with systemic lupus erythematosus (SLE), suggesting that bone marrow may be a 25 target organ in SLE. Our objective was to describe this bone marrow involvement. This registry is a nationwide retrospective study. Centers provided data concerning medical history, SLE manifestations, type of hematologic disorder, treatments and outcome. Bone marrow aspirations and/or biopsies were transferred for centralized review. Thirty patients from 19 centers were included. Central hematologic manifestations comprised bone marrow fibrosis (n = 17; 57%), pure red cell aplasia (n = 8; 27%), myelodysplastic syndrome (n = 3; 10%), aplastic anemia and agranulocytosis (n = 1; 3% each). Bone marrow involvement was diagnosed concomitantly with SLE in 12 patients. Bone marrow biopsies showed fibrosis in 19 cases, including one case of pure red cell aplasia and one case of agranulocytosis and variable global marrow cellularity. Treatments included corticosteroids (90%), hydroxychloroquine (87%), rituximab (33%), intravenous immunoglobulins (30%), mycophenolate mofetil (20%) and ciclosporine (20%). After a...Continue Reading
References
Mar 1, 1979·The American Journal of Medicine·J J FitchenD W Golde
Dec 1, 1991·American Journal of Hematology·S SumimotoT Hamamoto
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Oct 27, 1997·Arthritis and Rheumatism·M C Hochberg
Aug 7, 1998·Clinical Rheumatology·R M PereiraN H Yoshinari
Aug 8, 2001·American Journal of Clinical Pathology·R D BassR K Brynes
Jan 1, 2003·American Journal of Hematology·Vinod PullarkatRussell K Brynes
Mar 15, 2006·Seminars in Nephrology·Neerja AgrawalIan R Rifkin
Feb 6, 2007·Annals of the Rheumatic Diseases·Alastair L HepburnJustin C Mason
Jun 15, 2007·Hematology·Eśin BeyanMustafa Turan
Oct 22, 2011·Clinical Rheumatology·Gholam-Hossein AlishiriEhsan Saburi
May 4, 2012·Arthritis and Rheumatism·Michelle PetriLaurence S Magder
Nov 13, 2012·Annals of the Rheumatic Diseases·Nathalie Costedoat-ChalumeauUNKNOWN Group PLUS
Dec 19, 2013·Blood·Ronan DesmondCynthia E Dunbar
Oct 31, 2014·Rheumatology International·Emilie ChalayerPascal Cathébras
Apr 8, 2015·Annals of Hematology·Federico SimonettaCarlo Chizzolini
Nov 25, 2016·Blood·Robert T Means