Bone marrow involvement in systemic lupus erythematosus

QJM : Monthly Journal of the Association of Physicians
Emilie ChalayerPascal Cathébras

Abstract

Besides peripheral cytopenias, bone marrow abnormalities, such as fibrosis, pure red cell aplasia and aplastic anemia have been reported in patients with systemic lupus erythematosus (SLE), suggesting that bone marrow may be a 25 target organ in SLE. Our objective was to describe this bone marrow involvement. This registry is a nationwide retrospective study. Centers provided data concerning medical history, SLE manifestations, type of hematologic disorder, treatments and outcome. Bone marrow aspirations and/or biopsies were transferred for centralized review. Thirty patients from 19 centers were included. Central hematologic manifestations comprised bone marrow fibrosis (n = 17; 57%), pure red cell aplasia (n = 8; 27%), myelodysplastic syndrome (n = 3; 10%), aplastic anemia and agranulocytosis (n = 1; 3% each). Bone marrow involvement was diagnosed concomitantly with SLE in 12 patients. Bone marrow biopsies showed fibrosis in 19 cases, including one case of pure red cell aplasia and one case of agranulocytosis and variable global marrow cellularity. Treatments included corticosteroids (90%), hydroxychloroquine (87%), rituximab (33%), intravenous immunoglobulins (30%), mycophenolate mofetil (20%) and ciclosporine (20%). After a...Continue Reading

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Oct 31, 2014·Rheumatology International·Emilie ChalayerPascal Cathébras
Nov 25, 2016·Blood·Robert T Means

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Citations

Dec 17, 2017·American Journal of Hematology·Orly LeivaKatya Ravid
Jun 16, 2021·The Journal of Experimental Medicine·Francisco CaiadoMarkus G Manz

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