Bone marrow iron distribution, hepcidin, and ferroportin expression in renal anemia

Hematology
Liliana BârsanGabriel Mircescu

Abstract

Objectives The hepcidin-ferroportin system is involved in both conditions associated with iron-restricted erythropoiesis in renal anemia: iron deficiency and anemia of chronic disorders. As serum hepcidin could aid diagnosis, we investigated its relationships with bone marrow iron distribution, hepcidin-ferroportin expression in bone marrow cells, and peripheral iron indices in non-dialysis chronic kidney disease (CKD) patients. Methods Fifty-four epoetin and iron naive CKD patients entered this prospective, observational study. According to bone marrow iron distribution (iliac crest biopsy, Perls' stain), 26 had iron deficiency anemia, 21 anemia of chronic disorders and 7 had normal iron stores. Medullar hepcidin and ferroportin expression (immunofluorescence (IF), semiquantitative scales) and serum hepcidin (Hep25 - ELISA) were the main studied parameters. Results Low hepcidin and high ferroportin expression by erythroblast and macrophage were seen in iron deficiency anemia, while the opposites were true in anemia of chronic disorders. In regression analysis, higher Hep25 and ferritin predicted hepcidin expression (R(2)=0.48; P < 0.0001), while lower ferritin and Hep25 - predicted ferroportin expression (R(2) = 0.29; P = 0.00...Continue Reading

References

Aug 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K Kalantar-ZadehF C Luft
Mar 11, 2005·The New England Journal of Medicine·Guenter Weiss, Lawrence T Goodnough
Jun 4, 2005·Blood Cells, Molecules & Diseases·Xiao-Bing LiuDavid J Haile
May 2, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ngoc-Bich NguyenFunmei Yang
Aug 29, 2009·Kidney & Blood Pressure Research·Jolanta MalyszkoMichal Mysliwiec
Oct 27, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hilde P E PetersJack F M Wetzels
Jan 19, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Simona StancuGabriel Mircescu
Mar 20, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Joshua ZaritskyIsidro B Salusky
Sep 10, 2010·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Lavinia O BrătescuGabriel Mircescu
Sep 10, 2010·Blood·Lawrence Tim GoodnoughTomas Ganz
Oct 1, 2010·American Journal of Nephrology·Takeshi NakanishiYukiko Hasuike
Feb 25, 2011·Blood·Tomas Ganz
Sep 10, 2011·Blood·Carole Beaumont

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Citations

Mar 18, 2016·Clinical Kidney Journal·Lucia Del VecchioFrancesco Locatelli
May 18, 2017·Acta Haematologica·Cadiele Oliana ReichertCelso Spada
Jul 4, 2020·Critical Reviews in Food Science and Nutrition·Mauricio Restrepo-GallegoPatrícia H C Rondó
Jun 18, 2018·Clinical and Experimental Medicine·Daijun XiangChengbin Wang
Dec 19, 2017·Experimental and Therapeutic Medicine·Yang XuBen Ke
May 25, 2021·The Cochrane Database of Systematic Reviews·Maria Nieves Garcia-CasalJuan Pablo Peña-Rosas
Jun 29, 2021·Journal of Cellular and Molecular Medicine·Shinji KondoHiroko Isoda

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