Bone-marrow mesenchymal stem-cell administration significantly improves outcome after retinal ischemia in rats

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Biji MathewSteven Roth

Abstract

Ischemia-associated retinal degeneration is one of the leading causes of vision loss, and to date, there are no effective treatment options. We hypothesized that delayed injection of bone-marrow stem cells (BMSCs) 24 h after the onset of ischemia could effectively rescue ischemic retina from its consequences, including apoptosis, inflammation, and increased vascular permeability, thereby preventing retinal cell loss. Retinal ischemia was induced in adult Wistar rats by increasing intraocular pressure (IOP) to 130-135 mmHg for 55 min. BMSCs harvested from rat femur were injected into the vitreous 24 h post-ischemia. Functional recovery was assessed 7 days later using electroretinography (ERG) measurements of the a-wave, b-wave, P2, scotopic threshold response (STR), and oscillatory potentials (OP). The retinal injury and anti-ischemic effects of BMSCs were quantitated by measuring apoptosis, autophagy, inflammatory markers, and retinal-blood barrier permeability. The distribution and fate of BMSC were qualitatively examined using real-time fundus imaging, and retinal flat mounts. Intravitreal delivery of BMSCs significantly improved recovery of the ERG a- and b-waves, OP, negative STR, and P2, and attenuated apoptosis as evidenc...Continue Reading

References

Aug 27, 2003·Investigative Ophthalmology & Visual Science·Nobuo JoNarsing A Rao
Jul 1, 1963·The Journal of General Physiology·J E DOWLING
Nov 26, 2003·Investigative Ophthalmology & Visual Science·Steven RothChristine E Graham
Feb 10, 2004·Progress in Retinal and Eye Research·Neville N OsborneJosé Melena
May 27, 2004·Investigative Ophthalmology & Visual Science·Brad FortuneGeorge A Cioffi
Dec 30, 2004·Investigative Ophthalmology & Visual Science·Bang V BuiBrad Fortune
Sep 8, 2005·The Journal of Pharmacology and Experimental Therapeutics·Ortrud UckermannAndreas Bringmann
Apr 28, 2006·Investigative Ophthalmology & Visual Science·Steven RothVytautus Bindokas
Jan 2, 2007·Investigative Ophthalmology & Visual Science·Ling ZhengTimothy S Kern
Jan 16, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Andreas ReichenbachAndreas Bringmann
Nov 29, 2007·Progress in Retinal and Eye Research·A E Weymouth, A J Vingrys
Apr 1, 2008·Autophagy·Paul SaftigEeva-Liisa Eskelinen
Apr 2, 2008·Investigative Ophthalmology & Visual Science·Mohamed Al-ShabraweyRuth B Caldwell
Aug 30, 2008·Experimental Eye Research·John C DreixlerSteven Roth
Nov 8, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Liming LiQiushi Ren
Dec 17, 2008·Experimental Eye Research·John C DreixlerSteven Roth
Dec 17, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Na LiJia-qin Yuan
Jul 28, 2009·Experimental Eye Research·John C DreixlerSteven Roth
Oct 24, 2009·Investigative Ophthalmology & Visual Science·Thomas V JohnsonKeith R Martin
Jun 18, 2010·Investigative Ophthalmology & Visual Science·Steven F AbcouwerDavid A Antonetti
Apr 20, 2011·Experimental Eye Research·John C DreixlerSteven Roth
Jun 21, 2011·PloS One·Chengqun HuangRoberta A Gottlieb
Feb 22, 2012·Brain : a Journal of Neurology·Helen V Danesh-MeyerColin R Green
Mar 18, 2016·Journal of Neurophysiology·Xiaolan TangChristopher L Passaglia
May 11, 2016·Investigative Ophthalmology & Visual Science·Andreia GonçalvesDavid A Antonetti
Jun 11, 2016·Investigative Ophthalmology & Visual Science·Rosario AmatoGiovanni Casini
Jul 2, 2016·Investigative Ophthalmology & Visual Science·Steven RothMaciej S Lesniak
Oct 28, 2016·Progress in Retinal and Eye Research·Susanna S ParkJan A Nolta
Nov 26, 2016·Neurologic Clinics·Michael DattiloNancy J Newman

❮ Previous
Next ❯

Citations

Mar 23, 2019·Cutaneous and Ocular Toxicology·Ibrahim AhiskaliDurdu Altuner
Feb 26, 2019·International Journal of Retina and Vitreous·Parker E LudwigAdam C Janot
May 27, 2020·Autophagy·Biji MathewSteven Roth
Sep 29, 2017·Cellular and Molecular Life Sciences : CMLS·Weisi Lu, Xuri Li
Aug 17, 2019·Frontiers in Immunology·Henry CaplanCharles S Cox
Oct 9, 2018·Bio-protocol·Elena Redondo-CastroEmmanuel Pinteaux
Dec 22, 2019·Stem Cell Reviews and Reports·Barbora HermankovaVladimir Holan
Oct 18, 2020·Antioxidants·Paolo Giuseppe LimoliMarcella Nebbioso
Jan 8, 2021·Stem Cell Reviews and Reports·Sanjucta AdakBithiah Grace Jaganathan
Apr 14, 2021·Aesthetic Surgery Journal·Ricardo A Torres-GuzmanAntonio J Forte

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.