Apr 18, 2020

JuSpace: A tool for spatial correlation analyses of magnetic resonance imaging data with positron emission tomography derived neurotransmitter maps

BioRxiv : the Preprint Server for Biology
Juergen DukartS. B. Eickhoff

Abstract

Recent studies have shown that drug-induced spatial alteration patterns in resting state functional activity as measured using magnetic resonance imaging (MRI) are associated with the distribution of specific receptor systems targeted by respective compounds. Based on this approach, we introduce a Matlab-based toolbox (JuSpace) allowing for cross-modal correlation of MRI-based measures with positron emission tomography (PET) and single photon emission computed tomography (SPECT) derived estimates covering various receptor systems including dopaminergic, serotonergic, noradrenergic, and GABAergic (gamma-aminobutric acid) neurotransmission. We apply JuSpace to two datasets covering Parkinson's disease patients (PD) on and off levodopa and risperidone-induced changes in rsfMRI and cerebral blood flow (CBF). We correlate rsfMRI derived PD- and levodopa-induced local activity alterations with PET and SPECT maps covering the above neurotransmitter systems. Similarly, we correlate the effects of risperidone on CBF with respective maps. Consistently with the predominant neurodegeneration of dopaminergic and serotonergic system in PD, we find significant spatial associations between rsfMRI activity alterations in PD on and off levodopa ...Continue Reading

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