Bone marrow metastasis of rhabdomyosarcoma mimicking acute leukemia: a case report and review of the literature

Internal Medicine
Yuka AidaHikaru Kobayashi

Abstract

Bone marrow metastasis of rhabdomyosarcoma has been reported to be difficult to distinguish from acute leukemia. We herein describe a case of rhabdomyosarcoma with bone marrow metastasis mimicking acute lymphoblastic leukemia. A 29-year-old woman was admitted with thrombocytopenia, blast-like cells in the peripheral blood and a coagulation disorder. Bone marrow aspirates showed 94.8% blast-like cell infiltration (CD45(-), myeloperoxidase(-), and CD56(+)), and CT scan revealed the presence of an infiltrating mass in the nasal cavity. Based on a biopsy of the nasal cavity, the patient was diagnosed with rhabdomyosarcoma exhibiting bone marrow metastasis. She received chemotherapy, followed by radiation therapy, and has since remained alive for 26 months, as of the last follow-up.

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Citations

Aug 21, 2019·Clinical Case Reports·Bernardo López-AndradeAntonia Sampol
Nov 7, 2020·Indian Journal of Pathology & Microbiology·Rakhi V Jagdale, Jaydeep N Pol
Jul 17, 2021·Hematology, Transfusion and Cell Therapy·Carlos De Miguel SánchezJosé María Guinea de Castro

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