PMID: 6112792Mar 1, 1981Paper

Bone marrow morphology in patients in long-term treatment with azathioprine

Scandinavian Journal of Haematology
U SjögrenT Lindholm

Abstract

The bone marrow was morphologically analysed in 25 patients receiving long-term azathioprine therapy for chronic renal diseases or after a renal transplantation. There were no significant changes within the granulopoietic or lymphopoietic part of bone marrow even after 10 years of treatment. However, there was a significant "shift to the left" within erythropoiesis as well as greater frequencies of megaloblasts and sideroblasts. A significant increase of "erythroblastic islands" may indicate an increased death rate of defective erythroblasts. The changes within erythropoiesis in some of the patients were so pronounced that the possibility of a preleukaemic condition cannot be excluded.

References

Jan 21, 1978·Lancet·M H SheriffH A Lee
Feb 1, 1978·Scandinavian Journal of Haematology·U Sjögren
Jan 1, 1979·Scandinavian Journal of Haematology·U Sjögren
May 1, 1979·Cancer·J A EllertonM A Baker
Jan 1, 1977·Acta Haematologica·U Sjögren, H Thysell
Jul 1, 1976·Southern Medical Journal·W T SweeneyJ C Pierce
Mar 1, 1974·Acta Medica Scandinavica·E Cavallin-StåhlL Brandt
Oct 1, 1967·Acta Medica Scandinavica·M K Jensen

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Citations

Apr 16, 1998·International Journal of Urology : Official Journal of the Japanese Urological Association·C J KimY Nakane
Dec 10, 2014·Veterinary Clinical Pathology·Kimberly M PattulloMarion L Jackson
Jan 22, 1991·Klinische Wochenschrift·M Wolff, W Jelkmann

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