Bone marrow morphology is a strong discriminator between chronic eosinophilic leukemia, not otherwise specified and reactive idiopathic hypereosinophilic syndrome

Haematologica
Sa A WangAttilio Orazi

Abstract

Chronic eosinophilic leukemia, not otherwise specified can be difficult to distinguish from idiopathic hypereosinophilic syndrome according to the current World Health Organization guideline. To examine whether the morphological features of bone marrow might aid in the differential diagnosis of these two entities, we studied a total of 139 patients with a diagnosis of chronic eosinophilic leukemia, not otherwise specified (n=17) or idiopathic hypereosinophilic syndrome (n=122). As a group, abnormal bone marrow morphological features, resembling myelodysplastic syndromes, myeloproliferative neoplasm or myelodysplastic/myeloproliferative neoplasm, were identified in 40/139 (27%) patients: 16 (94%) of those with chronic eosinophilic leukemia and 24 (20%) of those with hypereosinophilic syndrome. Abnormal bone marrow correlated with older age (P<0.001), constitutional symptoms (P<0.001), anemia (P=0.041), abnormal platelet count (P=0.002), organomegaly (P=0.008), elevated lactate dehydrogenase concentration (P=0.005), abnormal karyotype (P<0.001), as well as the presence of myeloid neoplasm-related mutations (P<0.001). Patients with abnormal bone marrow had shorter survival (48.1 months versus not reached, P<0.001), a finding which...Continue Reading

Citations

Aug 15, 2018·American Journal of Hematology·Zhihong HuSa A Wang
Jul 3, 2019·American Journal of Clinical Pathology·Robert P HasserjianFalko Fend
Mar 12, 2020·Cytometry. Part B, Clinical Cytometry·Zhihong HuSa A Wang
Jun 12, 2020·American Journal of Clinical Pathology·Daiva M MattisChuanyi M Lu
Apr 24, 2018·Current Hematologic Malignancy Reports·Melanie C Dispenza, Bruce S Bochner
Nov 8, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Guilin TangSa A Wang
Sep 5, 2020·Journal of the National Comprehensive Cancer Network : JNCCN·Aaron T GerdsHema Sundar
Jan 10, 2021·International Journal of Molecular Sciences·Stefania StellaPaolo Vigneri
Mar 7, 2021·Pathology·David M RossPiers Blombery
Feb 10, 2020·The Journal of Molecular Diagnostics : JMD·Stephan BartelsUlrich Lehmann
May 16, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Guilin TangSa A Wang

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Methods Mentioned

BETA
flow cytometry
MDS

Software Mentioned

Illumina MiSeq Reporter

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