PMID: 7545353Sep 1, 1995Paper

Bone marrow of patients with active multiple myeloma: angiogenesis and plasma cell adhesion molecules LFA-1, VLA-4, LAM-1, and CD44

American Journal of Hematology
A VaccaF Dammacco

Abstract

Bone marrow plasma cells and stromal cells in multiple myeloma (MM) have been shown to be capable of releasing cytokines with angiogenic properties. Plasma cells can also express adhesion molecules controlling their adhesive interactions with endothelial cells. In the present study, we have evaluated by immunohistochemistry the extent of angiogenesis in the bone marrow of: a) 51 patients with active and non-active MM; b) 25 patients with monoclonal gammopathy of undetermined significance (MGUS). Plasma cells were investigated by flow cytometry for the expression of the adhesion molecules LFA-1, VLA-4, LAM-1, and CD44. The results showed that, while angiogenesis was very low or absent in patients with MGUS and non-active MM, it increased markedly in those with active MM. The highest detectability of plasma cell adhesion molecules, except LAM-1, was also found in these patients. The functional significance of these findings is unknown. Their consistent occurrence in the bone marrow of active myeloma patients, however, strongly suggests that more frequent adhesive interactions between plasma cells and their microvasculature underlie tumor dissemination.

References

May 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A MantovaniE Dejana
Dec 1, 1991·British Journal of Haematology·M M KawanoA Kuramoto
Jan 3, 1990·Journal of the National Cancer Institute·J Folkman
Jul 1, 1994·British Journal of Haematology·A VaccaF Dammacco
Feb 1, 1993·American Journal of Surgery·W G Cheadle
Apr 1, 1993·Clinical and Experimental Immunology·F MericoF Caligaris-Cappio
Jan 1, 1993·Acta Haematologica·H HataK Takatsuki

❮ Previous
Next ❯

Citations

May 10, 2002·International Journal of Hematology·Renchi Yang, Zhong Chao Han
Jul 17, 2013·Frontiers of Medicine·Miao XuJun Peng
Apr 18, 2006·Current Treatment Options in Oncology·Joan Bladé, Laura Rosiñol
Feb 20, 2010·Medical Oncology·Jacob P LaubachKenneth C Anderson
Dec 9, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A VaccaF Dammacco
Mar 12, 2002·British Journal of Haematology·Tsuyoshi IwasakiEizo Kakishita
Jul 11, 2000·British Journal of Haematology·K L Talks, A L Harris
Nov 25, 2000·British Journal of Haematology·M H Mangi, A C Newland
Jun 14, 2001·British Journal of Haematology·J BladéE Montserrat
Nov 24, 1999·The New England Journal of Medicine·S SinghalB Barlogie
Feb 16, 2002·Journal of Hematotherapy & Stem Cell Research·Jin-Young BaekAyalew Tefferi
May 2, 2002·Anti-cancer Drugs·S Zweegman, P C Huijgens
Mar 15, 2006·European Journal of Haematology·Rosiñol LauraEmili Montserrat
Jun 1, 1997·Occupational and Environmental Medicine·L SoleoV Foa
Dec 23, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joan BladéRobert A Kyle
Jun 1, 2004·International Journal of Hematology·Yutaka HattoriYasuo Ikeda
May 8, 2014·International Reviews of Immunology·Leonardo MirandolaMaurizio Chiriva-Internati
Jul 12, 2003·Leukemia & Lymphoma·V Eleutherakis-PapaiakovouM A Dimopoulos
Oct 19, 2013·Seminars in Oncology·Jacob LaubachKenneth Anderson
Nov 28, 2012·Leukemia Research·Ivan Borrello
Feb 18, 2016·BioMed Research International·Lavinia RaimondiNicola Amodio
Feb 9, 2011·Clinical Biochemistry·Suhasini JoshiAlpana Sharma
Aug 14, 2002·Mayo Clinic Proceedings·S Vincent RajkumarUNKNOWN Mayo Clinic Myeloma, Amyloid, and Dysproteinemia Group
Aug 2, 2006·Clinical Lymphoma & Myeloma·Peter M Voorhees, Robert Z Orlowski
Sep 10, 2003·Pathology·Efstratios PatsourisTheodore Kordossis
Jan 8, 2000·Hematology/oncology Clinics of North America·T E Witzig
Dec 17, 2014·Immunological Reviews·Yawara KawanoIrene M Ghobrial
Aug 1, 1996·Japanese Journal of Cancer Research : Gann·T TatsumiM Nakagawa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.