PMID: 15333000Aug 31, 2004Paper

Bone marrow origin of cells with capacity for homing and differentiation to esophageal squamous epithelium

Radiation Research
M W EpperlyJ S Greenberger

Abstract

Our goal was to determine whether esophageal progenitor cells could be isolated from adult mouse esophagus or bone marrow and shown to home to and proliferate in the irradiated esophagus of recipient mice. Esophageal progenitor cells were isolated from adult male C3H/HeNsd or C57BL/6J green fluorescent protein (GFP(+)) mice by a serial in vitro preplate technique or the technique of side population cell sorting. When injected intravenously (i.v.), these cells homed to the 30-Gy-irradiated esophagus of GFP(-) female recipient mice and formed donor-origin esophageal foci. GFP(+) whole murine bone marrow cells injected i.v. also formed donor-origin esophageal squamous cell foci and protected recipient GFP(-) mice from upper-body irradiation in a cell dose-dependent manner. Marrow chimeric GFP(-) mice reconstituted with GFP(+) cells showed migration of GFP(+) marrow cells to the esophagus after 30 Gy irradiation. Purified esophageal progenitor cells isolated from first-generation preplate cell recipients engrafted after i.v. injection to the esophagus of second-generation-irradiated recipient mice. These data establish that esophageal progenitor cells can home to the irradiated esophagus and show limited differentiation capacity to...Continue Reading

References

Sep 1, 1989·International Journal of Radiation Oncology, Biology, Physics·N H Terry, E L Travis
Nov 1, 1974·Radiology·T L Phillips, G Ross
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J S GreenbergerR J Eckner
Apr 1, 1996·The Journal of Experimental Medicine·M A GoodellR C Mulligan
May 15, 1999·Science·B E PetersenJ P Goff
Jul 17, 1999·Trends in Neurosciences·C N Svendsen, A G Smith
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·G C KopenD G Phinney
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·K A JacksonM A Goodell
Oct 4, 2000·Nature Neuroscience·R GalliA L Vescovi
Jun 26, 2002·The Journal of Cell Biology·Akira TsujimuraE Lynette Wilson
Nov 9, 2002·Experimental Hematology·Atsushi Asakura, Michael A Rudnicki
Mar 22, 2003·American Journal of Respiratory Cell and Molecular Biology·Michael W EpperlyJoel S Greenberger
Oct 14, 2003·Nature·Manuel Alvarez-DoladoArturo Alvarez-Buylla
Dec 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth A Olmsted-DavisAlan R Davis
Dec 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yu-An CaoChristopher H Contag

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Citations

Mar 25, 2011·Nature Reviews. Cancer·Adrian C BeggConchita Vens
Jul 3, 2013·Nature Reviews. Drug Discovery·Everett J ModingDavid G Kirsch
Aug 19, 2007·Gene Therapy·J S Greenberger
Jan 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Xu CaoFrank J Frassica
May 3, 2012·Proceedings of the American Thoracic Society·Susan D ReynoldsMoumita Ghosh
Aug 6, 2008·Stem Cell Reviews·Daniel CroaghPritinder Kaur
Nov 30, 2010·Gastrointestinal Endoscopy Clinics of North America·David H Wang, Rhonda F Souza
Mar 3, 2009·Seminars in Radiation Oncology·Rob P CoppesIsabelle M A Lombaert
Mar 3, 2009·Seminars in Radiation Oncology·Joel S Greenberger, Michael Epperly
Dec 24, 2008·Seminars in Pediatric Surgery·Augusto ZaniPaolo De Coppi
Jan 17, 2008·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·G SarosiStuart Jon Spechler
Jul 20, 2007·Journal of Cellular and Molecular Medicine·Virgil PăunescuErhard Seifried
Feb 24, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Harit KapoorSumeet K Mittal
Jan 1, 2011·Cancers·Punit KaurAlexzander Asea
Jan 20, 2016·Antioxidants·Joel GreenbergerMichael Epperly
Apr 1, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Margarita ZhuravlevaPaolo Macchiarini
Oct 1, 2011·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Myung Shin Jeon, Soon Sun Hong
Aug 4, 2020·World Journal of Stem Cells·Yang Gao, Shi-Zhu Jin
Apr 21, 2018·Digestive Diseases and Sciences·Wei Zhang, David H Wang

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