Bone Marrow Stimulation Technique Augmented by an Ultrapurified Alginate Gel Enhances Cartilage Repair in a Canine Model

The American Journal of Sports Medicine
Rikiya BabaNorimasa Iwasaki

Abstract

The optimal treatment for a medium- or large-sized cartilage lesion is still controversial. Since an ultrapurified alginate (UPAL) gel enhances cartilage repair in animal models, this material is expected to improve the efficacy of the current treatment strategies for cartilage lesions. The bone marrow stimulation technique (BMST) augmented by UPAL gel can induce hyaline-like cartilage repair. Controlled laboratory study. Two cylindrical osteochondral defects were created in the patellar groove of 27 beagle dogs. A total of 108 defects were divided into 3 groups: defects without intervention (control group), defects with the BMST (microfracture group), and defects with the BMST augmented by implantation of UPAL gel (combined group). At 27 weeks postoperatively, macroscopic and histological evaluations, micro-computed tomography assessment, and mechanical testing were performed for each reparative tissue. The defects in the combined group were almost fully covered with translucent reparative tissues, which consisted of hyaline-like cartilage with well-organized collagen structures. The macroscopic score was significantly better in the combined group than in the control group ( P < .05). The histological scores in the combined gr...Continue Reading

References

Oct 6, 1994·The New England Journal of Medicine·M BrittbergL Peterson
Jan 1, 1993·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Y MatsusueH Hama
Oct 31, 1997·The Journal of Bone and Joint Surgery. American Volume·H A BreinanM Spector
Dec 16, 1998·The American Journal of Sports Medicine·B R MandelbaumL Peterson
May 20, 2000·Clinical Orthopaedics and Related Research·L PetersonA Lindahl
Dec 16, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·H A BreinanM Spector
Jun 5, 2002·The Journal of Bone and Joint Surgery. British Volume·M OchiJ Iwasa
Sep 10, 2002·Clinical Orthopaedics and Related Research·J A Buckwalter
Feb 6, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·C R LeeM Spector
May 2, 2003·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·J Richard SteadmanWilliam G Rodkey
Mar 5, 2004·The Journal of Bone and Joint Surgery. American Volume·Gunnar KnutsenOddmund Johansen
May 18, 2004·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Alberto GobbiKonrad Malinowski
Apr 22, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Christoph ErggeletChristian Kaps
Feb 4, 2010·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·J GilleP Behrens
Feb 5, 2010·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Andreas H GomollElizaveta Kon
Sep 8, 2010·Bone·Michael DoubeSandra J Shefelbine
Sep 25, 2010·The Journal of Bone and Joint Surgery. American Volume·Norimasa IwasakiAkio Minami
May 22, 2013·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·M L PachowskyM Blanke
Jul 11, 2013·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Thomas R NiethammerMatthias F Pietschmann
May 31, 2014·The Journal of Bone and Joint Surgery. American Volume·Syed Z NawazBaljinder S Dhinsa

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Citations

Jan 1, 2019·The American Journal of Sports Medicine·WooYoung KimNorimasa Iwasaki
Feb 16, 2021·Frontiers in Bioengineering and Biotechnology·Sarah DavisTosca Roncada
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Maria NelsonJulian R Jones

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Methods Mentioned

BETA
light microscopy
biopsy

Software Mentioned

JMP Pro
SAS
Image J
Bone J

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