Bone Marrow Stromal Cells Associated with Poly L-Lactic-Co-Glycolic Acid (PLGA) Nanofiber Scaffold Improve Transected Sciatic Nerve Regeneration

Iranian Journal of Biotechnology
Gholamreza KakaAlireza Mohammadi

Abstract

Background: Although peripheral nerves show capacity for regeneration after injury to a certain extent, the extent of regeneration is not remarkable. Previous studies have suggested that through the production of growth factors or extracellular matrix components, mesenchymal stem cells may enhance nerve regeneration. Objectives: In the present study, the therapeutic potency of the Bone Marrow Stromal Cells (BMSCs) associated with Poly L-lactic-co-glycolic acid (PLGA) nanofiber Scaffolds on rat sciatic nerve repair was evaluated. Material and Methods: Thirty adult male Wistar rats (220-250 g) were divided randomly into six groups, including control 1 (transected sciatic nerve), control 2 (transected sciatic nerve and stitched), Sham, PLGA, BMSCs, and PLGA+BMSCs. Functional recovery was evaluated at the end of 2nd, 4th, 6th, and 8th weeks after surgery using sciatic functional index (SFI) and hot water test. After killing all rats at the end of 8th week, their sciatic nerves were removed, fixed, and processed for the histological examination and analysis by the Motic software. Results: A significant recovery of the sciatic nerve function was observed in the PLGA+BMSCs transplanted group at the 8th week after surgery as demonstrat...Continue Reading

References

Jan 5, 2002·Journal of Biomedical Materials Research·Pamela J VandeVordPaul H Wooley
Apr 12, 2003·Current Opinion in Hematology·Chirag Joshi, Tariq Enver
Dec 25, 2010·In Vitro Cellular & Developmental Biology. Animal·Guanglin WangHui Wu
Jun 21, 2011·International Journal of Molecular Medicine·Guibo LiuXiaojie Tong
Jun 23, 2011·In Vitro Cellular & Developmental Biology. Animal·Shin-ichiro OgawaTeruyuki Nagamune
Nov 26, 2011·The International Journal of Neuroscience·Gholam Reza KakaHadi Kazemi
Jan 24, 2012·Journal of Asian Natural Products Research·Laxminarain MisraNeelam S Sangwan
Jul 23, 2015·Cell Journal·Alireza MohammadiHossein Baharvand

❮ Previous
Next ❯

Citations

Feb 1, 2019·Expert Opinion on Biological Therapy·Sara Sayad-FathiArash Zaminy
Dec 12, 2018·Neural Regeneration Research·Pei-Xun ZhangBao-Guo Jiang
Jul 30, 2019·Bioprinting·Ting GuoJohn P Fisher

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.