Bone Marrow T Cells and the Integrated Functions of Recirculating and Tissue-Resident Memory T Cells

Frontiers in Immunology
Francesca Di Rosa, Thomas Gebhardt

Abstract

Changes in T cell trafficking accompany the naive to memory T cell antigen-driven differentiation, which remains an incompletely defined developmental step. Upon priming, each naive T cell encounters essential signals - i.e., antigen, co-stimuli and cytokines - in a secondary lymphoid organ; nevertheless, its daughter effector and memory T cells recirculate and receive further signals during their migration through various lymphoid and non-lymphoid organs. These additional signals from tissue microenvironments have an impact on immune response features, including T cell effector function, expansion and contraction, memory differentiation, long-term maintenance, and recruitment upon antigenic rechallenge into local and/or systemic responses. The critical role of T cell trafficking in providing efficient T cell memory has long been a focus of interest. It is now well recognized that naive and memory T cells have different migratory pathways, and that memory T cells are heterogeneous with respect to their trafficking. We and others have observed that, long time after priming, memory T cells are preferentially found in certain niches such as the bone marrow (BM) or at the skin/mucosal site of pathogen entry, even in the absence of ...Continue Reading

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Citations

Feb 2, 2019·European Journal of Immunology·Marieke GoedhartMartijn A Nolte
Feb 11, 2020·Journal of Leukocyte Biology·Anne-Laure Chetaille NézondetMartin Pelletier
Apr 16, 2019·Frontiers in Immunology·Cristina SobacchiAnna Villa
Jul 25, 2019·Frontiers in Endocrinology·Paola de CandiaGiuseppe Matarese
Apr 30, 2019·Frontiers in Immunology·Christian H BucherKatharina Schmidt-Bleek
Nov 9, 2017·European Journal of Immunology·Martijn A NolteJens Geginat
Dec 16, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bennett DavenportDirk Homann
Mar 11, 2020·Frontiers in Immunology·Valérie JanelleJean-Sébastien Delisle
Jun 16, 2018·Frontiers in Immunology·Shiki Takamura
Mar 21, 2019·European Journal of Immunology·Maria Fernanda PascuttiMartijn A Nolte
Oct 27, 2020·Journal of Leukocyte Biology·Gary D LukerJohann Zimmermann

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