PMID: 1127Dec 1, 1975

Bone marrow transplantation for aplastic anaemia from a HL-A and MLC-identical unrelated donor

Blut
H P LohrmannH Heimpel

Abstract

Bone-marrow transplantation (BMT) from an unrelated, HL-A-phenotype-identical, MLC-negative donor was performed in a 31 year old woman with severe longlasting aplastic anemia. In vitro assays failed to demonstrate humoral or cellular sensitization of the recipient against donor-type antigens. Following conditioning with cyclophosphamide, prompt but only transient engraftment of the transplant occurred accompanied by signs of mild graft-versus-host-disease (GVHD) of the liver. The results of a second bone marrow transplantation from the same donor cannot be evaluated due to early death of the recipient. It is concluded that bone marrow from unrelated, HL-A and MLC-identical donors may engraft without severe GVHD. Rejection of the graft in our patient may have been related to greater antigenic differences that can be expected to exist between HL-A and MLC-identical unrelated individuals than between HL-A and MLC-identical siblings. However, insufficient preparative immunosuppression with cyclophosphamide due to severe hepatic hemosiderosis appears equally likely as the cause of graft rejection. The possibly increased risk of graft rejection or severe GVHD should not preclude the use of unrelated HL-A and MLC-identical marrow dono...Continue Reading

References

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Citations

Sep 7, 2001·Current Opinion in Immunology·E PetersdorfJ A Hansen
Dec 15, 1977·The New England Journal of Medicine·R J O'ReillyR A Good
Sep 4, 1980·The New England Journal of Medicine·J A HansenE R Giblett
Mar 4, 1993·The New England Journal of Medicine·N A KernanJ McCullough
Jun 3, 1977·Virchows Archiv. A, Pathological Anatomy and Histology·B HeymerO Haferkamp
Oct 1, 1983·Clinics in Haematology·E J YunisC A Alper
Dec 10, 1990·Transfusion Science·M R Howard
Jan 1, 1986·Current Problems in Cancer·M M Bortin
Aug 7, 2001·Reviews in Clinical and Experimental Hematology·M de Lima, R Champlin
Feb 21, 2006·Bone Marrow Transplantation·J R PasswegC Bredeson
Nov 6, 2007·Bone Marrow Transplantation·R ViollierJ R Passweg
Jan 1, 1982·Scandinavian Journal of Haematology·G LucarelliB Dallapiccola

Related Concepts

Hypoplastic Anemia
Marrow
Bone Marrow Cells
Cyclophosphamide, (S)-Isomer
Graft Rejection
Graft Vs Host Reaction
Hemosiderosis
HLA Antigens
Lymphocyte Culture Test, Mixed
Liver Dysfunction

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