Bone marrow transplantation in low-grade non-Hodgkin's lymphoma

Leukemia & Lymphoma
H M Lazarus

Abstract

The low-grade histologic types constitute one quarter of all non-Hodgkin's lymphomas (NHL). Conventional chemotherapy and chemo-radiation therapy have failed to significantly alter the course of this disease, and most patients eventually succumb to lymphoma. Despite the fact that NHLs exhibit a steep dose-response relation to cytotoxic therapy, fewer than 30% of eligible patients undergo bone marrow transplantation. Reasons for fewer patients receiving this course of treatment include: elderly patient population, extensive previous chemotherapy and/or radiation therapy, high incidence of bone marrow involvement, and transformation to higher grade NHLs. In recent years, improvements in several areas have enhanced the therapeutic index for bone marrow transplantation. These advances include the use of more effective preparative regimens, recombinant hematopoietic growth factors, extended-spectrum antibiotics, and an increased expertise in blood transfusion techniques and practices. Other, more effective strategies include sophisticated in vitro bone marrow purging approaches and peripheral blood progenitor cell collection. As a result, more patients have been able to receive dose-intensive therapy followed by hematopoietic cellul...Continue Reading

References

Jul 1, 1977·Cancer·S ReddyF R Hendrickson
Aug 1, 1976·Annals of Internal Medicine·B A ChabnerV T DeVita
Mar 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A C KayL D Piro
May 11, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J R RedmanM J Keating
Aug 8, 1992·BMJ : British Medical Journal·A McMillanD C Linch
Nov 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H M LazarusD Topolsky
Nov 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R ChopraP Ernst
Nov 5, 1992·The New England Journal of Medicine·R V SmalleyE C Borden
Jun 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D J WeisdorfM M Oken
Jul 1, 1991·British Journal of Cancer·J S WhelanT A Lister
Dec 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J W SweetenhamJ M Whitehouse
Jan 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H S HochsterM J O'Connell
Sep 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C G PriceT A Lister
Jun 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M KörblingW Hunstein
Jun 15, 1991·Annals of Internal Medicine·A SurboneR P Gale
Apr 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F J CummingsM J O'Connell
Feb 7, 1990·Journal of the National Cancer Institute·L A VanderMolenL C Hartmann
Feb 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K S ZuckermanJ A Reeves
Apr 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P ColombatA Najman
Apr 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F B PetersenR Storb
May 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A S FreedmanL Heflin
Jun 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L W KwakS J Horning
Sep 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S I BearmanE D Thomas
May 18, 1989·Nature·S Kwok, R Higuchi
Nov 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J G GribbenJ D Richards
Nov 1, 1989·The American Journal of Medicine·R A RobbinsW P Vaughan
Jan 1, 1987·International Journal of Immunopharmacology·E L LarssonT Stålhandske
Aug 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S C GulatiI Cunningham
Jun 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P McLaughlinD O Dixon

❮ Previous
Next ❯

Citations

Jan 1, 1996·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Z S PavleticJ O Armitage
Jul 15, 1998·International Journal of Pediatric Otorhinolaryngology·S DubeyJ T Morewaya
Feb 13, 2001·International Journal of Radiation Oncology, Biology, Physics·A D MurthaR Hoppe
Sep 21, 2000·Critical Reviews in Oncology/hematology·N SabaA Keating
Jul 15, 2011·International Journal of Dentistry·Wenqun SongHirohisa Arakawa
May 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stanton L Gerson
Oct 2, 2015·Cell Transplantation·Tiziana SquillaroUmberto Galderisi
Jan 21, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Mark S FreedmanUNKNOWN MSCT Study Group
Apr 21, 2010·Nature Reviews. Neurology·Gianvito MartinoUNKNOWN Stem Cells in Multiple Sclerosis (STEMS) Consensus Group
Sep 18, 2007·Expert Review of Neurotherapeutics·Dimitrios Karussis, Ibrahim Kassis
Nov 27, 2019·International Journal of Molecular Sciences·Marta KotMarcin Majka

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.