Bone marrow tryptase as a possible diagnostic criterion for adult systemic mastocytosis

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
C Bulai LivideanuC Paul

Abstract

Mastocytosis is difficult to diagnose, especially when systemic mast cell activation symptoms are not present or involve only one extracutaneous organ. The main objective was to evaluate the accuracy of the bone marrow tryptase level in the diagnosis of systemic mastocytosis in patients with a clinical suspicion of mastocytosis. We included all adult patients evaluated in our centre between December 2009 and 2013 for suspected mastocytosis as part of a standardized procedure and who had a bone marrow and serum tryptase assay on the same day. The diagnosis of systemic mastocytosis was established on the basis of the World Health Organization criteria as the gold standard. The accuracy of the bone marrow tryptase level in the diagnosis of systemic mastocytosis was assessed by a receiver operating characteristics curve analysis. The different sensitivity and specificity values, corresponding to the set of possible bone marrow tryptase level cut-off values, were estimated with 95% confidence intervals. Seventy-three patients were included. The diagnosis of systemic mastocytosis was established in 43 patients (58.9%). The median bone marrow tryptase level was 423 μg/L [95% CI: 217-868] in the systemic mastocytosis group and 7.5 μg/L...Continue Reading

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Citations

Apr 23, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·M FradetC Bulai Livideanu
Mar 9, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y DegboéM Laroche
Mar 7, 2021·Orphanet Journal of Rare Diseases·Fatma JendoubiCristina Bulai Livideanu

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