Bone mass and the CAG and GGN androgen receptor polymorphisms in young men.

PloS One
Amelia Guadalupe-GrauJosé A L Calbet

Abstract

To determine whether androgen receptor (AR) CAG (polyglutamine) and GGN (polyglycine) polymorphisms influence bone mineral density (BMD), osteocalcin and free serum testosterone concentration in young men. Whole body, lumbar spine and femoral bone mineral content (BMC) and BMD, Dual X-ray Absorptiometry (DXA), AR repeat polymorphisms (PCR), osteocalcin and free testosterone (ELISA) were determined in 282 healthy men (28.6+/-7.6 years). Individuals were grouped as CAG short (CAG(S)) if harboring repeat lengths of < or = 21 or CAG long (CAG(L)) if CAG > 21, and GGN was considered short (GGN(S)) or long (GGN(L)) if GGN < or = 23 or > 23. There was an inverse association between logarithm of CAG and GGN length and Ward's Triangle BMC (r = -0.15 and -0.15, P<0.05, age and height adjusted). No associations between CAG or GGN repeat length and regional BMC or BMD were observed after adjusting for age. Whole body and regional BMC and BMD values were similar in men harboring CAG(S), CAG(L), GGN(S) or GGN(L) AR repeat polymorphisms. Men harboring the combination CAG(L)+GGN(L) had 6.3 and 4.4% higher lumbar spine BMC and BMD than men with the haplotype CAG(S)+GGN(S) (both P<0.05). Femoral neck BMD was 4.8% higher in the CAG(S)+GGN(S) comp...Continue Reading

References

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Citations

Feb 25, 2011·The Journal of Clinical Endocrinology and Metabolism·Braxton D Mitchell, Laura M Yerges-Armstrong
Jan 29, 2014·Current Opinion in Endocrinology, Diabetes, and Obesity·Michael S Irwig
Mar 8, 2013·Evolutionary Applications·Calen P Ryan, Bernard J Crespi
Oct 1, 2015·International Journal of Endocrinology·Giacomo TirabassiGiancarlo Balercia
Feb 18, 2011·Clinical Orthopaedics and Related Research·Ran YanovichDaniel S Moran

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Methods Mentioned

BETA
X-ray
Enzyme-Linked Immunosorbent Assay
PCR

Software Mentioned

Gene Scan Analysis

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