Bone mass, lean mass, and fat mass: same genes or same environments?

American Journal of Epidemiology
T V NguyenJ A Eisman

Abstract

The contributions of genetic and environmental factors to the association among bone mineral density (BMD), lean mass, and fat mass were assessed in the Sydney Twin Study of Osteoporosis (Australia), 1995-1996, in 57 monozygotic and 55 dizygotic female twin pairs of Caucasian background, aged 52.8 (standard deviation, 13) years. In multiple regression analysis, lean mass was a significant determinant of areal BMD; however, fat mass was a principal determinant of volumetric BMD. Univariate model-fitting analyses indicated that 80% and 65% of variance of lean mass and fat mass, respectively, were attributable to genetic factors. The estimated heritability of BMD for lumbar spine, femoral neck, and total body BMD was 78%, 76%, and 79%, respectively. Multivariate analyses suggested that, while the association between lean mass and fat mass was attributable mainly to environmental factors (re = 0.53, p < 0.01), the association among the three BMD sites was attributable to both genetic and environmental factors (rg = 0.64-0.75, p < 0.001; re = 0.57-0.70, p < 0.001). Furthermore, genetic factors that affect lean mass or fat mass have minor effects on BMD. It is concluded that lean mass and fat mass, as well as bone density, are under ...Continue Reading

Citations

Mar 24, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H BlainE Le Bihan
Apr 20, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Joanna MakoveyPhilip Sambrook
May 13, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Chatlert PongchaiyakulRajata Rajatanavin
Jul 19, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Fei-Yan DengHong-Wen Deng
Sep 21, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Carlos Cure-CureJosé L Ferretti
Jun 10, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J-H ParkY S Park
Sep 22, 2007·Calcified Tissue International·Carles Vilariño-GüellMatthew A Brown
Nov 26, 2010·Calcified Tissue International·Roderick J Clifton-BlighPhilip N Sambrook
Dec 20, 2008·European Journal of Applied Physiology·Rawad Philippe El HageChristelle Jaffré
Jun 27, 2007·Journal of Bone and Mineral Metabolism·Marco Di MonacoAlberto Cavanna
Nov 1, 2011·Age·Nuria Garatachea, Alejandro Lucía
Jul 23, 2005·Current Osteoporosis Reports·Toby Andrew, Alex J Macgregor
Aug 2, 2012·Current Osteoporosis Reports·Tuan V Nguyen, John A Eisman
Mar 29, 2003·Mechanisms of Ageing and Development·Sophie Gillette-GuyonnetHélène Grandjean
Oct 26, 2002·Bone·G El-Hajj FuleihanP Rizk
Apr 2, 2003·Bone·Bente Lomholt LangdahlErik Fink Eriksen
Dec 9, 2008·Genetics Research·Michael S ReichJames M Cheverud
May 31, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·A VuilleminC Jeandel
Sep 27, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ricardo Moreno LimaRicardo Jacó de Oliveira
Jul 1, 2008·BMC Medical Genetics·Bich N H TranTuan V Nguyen
Mar 30, 2010·BMC Musculoskeletal Disorders·Lan T Ho-PhamTuan V Nguyen
Oct 3, 2008·Arthritis Research & Therapy·Emma L Duncan, Matthew A Brown
Oct 1, 2000·Environmental Health and Preventive Medicine·M HaraM Nishizumi
Aug 26, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G M HowardJ A Eisman
Jan 20, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M E DanielsonL H Kuller
Oct 12, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G Jones, T V Nguyen
Mar 7, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T V NguyenJ A Eisman
Apr 6, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T V NguyenJ A Eisman
Jul 14, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T V Nguyen, J A Eisman
Jul 14, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D R TaaffeT B Harris
Mar 29, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Vasi NaganathanPhilip Sambrook
May 15, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sun H LeeUNKNOWN EPIDOS Group. Epidemiologie de l'Osteoporose Study
Nov 5, 1999·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·H W DengR R Recker
Dec 19, 2001·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·H W DengR R Recker
Apr 2, 2014·Calcified Tissue International·Nerea Hernandez-de SosaJordi Casademont
Aug 7, 2014·Current Osteoporosis Reports·Alex IrelandJörn Rittweger
Nov 5, 2014·Journal of Diabetes and Metabolic Disorders·Zahra MohammadiHamid Reza Barikani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
L FlickerJ D Wark
The Journal of Clinical Investigation
N A PocockS Eberl
Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
I R ReidR W Ames
© 2021 Meta ULC. All rights reserved