Bone metabolism and gonad function in male patients undergoing liver transplantation: a two-year longitudinal study

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
A FloreaniG Luisetto

Abstract

Osteodystrophy is a major complication of end-stage liver disease, especially in postmenopausal women. Our aim in this study was to evaluate bone metabolism and gonad function in men undergoing orthotopic liver transplantation (OLTx). Twenty-three consecutive men (mean age 48+/-13 years) evaluated for OLTx were studied, assessing the following parameters at baseline and 3, 6, 12 and 24 months after OLTx: lumbar spine (L2-L4) bone mineral density (BMD), parathyroid hormone (PTH), osteocalcin (BGP), 25-hydroxyvitamin D (25OHD), free testosterone (FT) and gonadotropins (FSH, LH). At baseline, 12 patients (52%) had a T-score <-2.5 SD and the mean BMD was 0.806+/-0.11 g/cm2 (range 0.470-1.045 g/cm2). The BMD was lower 3 months after OLTx and significantly higher 12 and 24 months after OLTx. A significant increase in serum BGP was observed at 6, 12 (p<0.05) and 24 months (p<0.005) after OLTx. The mean serum PTH level was 26.6+/-3.1 pg/ml at baseline and increased significantly at 12 and 24 months (to 49.4+/-9.9 and 61.2+/-10.1 pg/ml, respectively; p<0.05). 25OHD serum levels were low at baseline and returned to the normal range after 12 and 24 months (baseline, 8.73+/-1.54 ng/ ml; 12 months, 16.4+/-2.6 ng/ml; 24 months, 17.67+/-3.1 n...Continue Reading

Citations

Jan 6, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E M Stein, E Shane
Sep 2, 2003·Gastroenterology·William D LeslieUNKNOWN American Gastroenterological Association Clinical Practice Commitee
Jun 19, 2008·Journal of Endocrinological Investigation·C ForestaD D'Amico
Nov 7, 2007·Endocrinology and Metabolism Clinics of North America·Emily SteinElizabeth Shane
Nov 13, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Adi CohenElizabeth Shane
Jan 16, 2007·Alimentary Pharmacology & Therapeutics·A Sethi, R T Stravitz
Jul 10, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Deirdre A KellyUNKNOWN American Society of Transplantation
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Mar 20, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Charlotte G KrolNeveen At Hamdy
May 11, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Karim GarianiLorenzo A Orci
Mar 6, 2015·Revista do Colégio Brasileiro de Cirurgiões·Bruno T ZachariasJosé Luiz de Godoy
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Feb 27, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Núria Guañabens, Albert Parés
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Nov 9, 2011·Journal of Pediatric Gastroenterology and Nutrition·Wolfgang HöglerDeirdre Kelly
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