Bone metabolism in obese rats programmed by early weaning

Metabolism: Clinical and Experimental
L de Albuquerque MaiaEgberto G de Moura

Abstract

Obesity and osteoporosis seem to have a common pathogenesis, especially because bone and adipose tissue have common origins. Since early weaning (EW) decreases adipogenesis and osteogenesis in neonate, further programming for obesity and hyperleptinemia, we hypothesized that these changes in adipogenesis could affect bone metabolism. Lactating rats were separated into 3 groups: control - dams whose pups ate milk throughout lactation; mechanical EW (MEW) - dams were involved with a bandage interrupting suckling in the last 3days of lactation; pharmacological EW (PEW) - dams were bromocriptine-treated (0.5mg/twice a day via intraperitoneal injection) 3days before weaning. The adult offspring was subjected to dual-energy X-ray absorptiometry and bone tissue was also evaluated by computed tomography, microcomputed tomography and biomechanical tests, beyond serum analyses. MEW and PEW presented higher total bone mineral density (BMD), total bone mineral content, spine BMD and bone area in postnatal day 150 (PN150). In PN180, both groups also presented increase of these parameters and higher femur BMD and fourth lumbar vertebra (LV4) BMD, femoral head radiodensity and LV4 vertebral body radiodensity, trabecular number, stiffness and ...Continue Reading

References

Jul 1, 1992·The Journal of Clinical Endocrinology and Metabolism·I R ReidT F Cundy
Jul 1, 1991·Clinical Physiology·J HaarboC Christiansen
Oct 1, 1972·The Journal of Clinical Endocrinology and Metabolism·A E SchindlerE Friedrich
Dec 11, 1993·BMJ : British Medical Journal·D J BarkerC H Fall
Feb 1, 1996·Acta Paediatrica·N J BishopA Lucas
Sep 2, 1998·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·V BrahmabhattI Ziv
Jul 16, 1999·BMJ : British Medical Journal·R von KriesH von Voss
May 4, 2000·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·G JonesT Dwyer
Oct 12, 2000·Regulatory Peptides·C M SteppanA G Swick
May 23, 2001·JAMA : the Journal of the American Medical Association·M W GillmanG A Colditz
May 31, 2001·The Journal of Nutritional Biochemistry·M C.F. PassosE Gaspar de Moura
Dec 26, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A D LieseS K Weiland
Feb 15, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·K E BergmannU Wahn
Mar 15, 2003·Molecular Endocrinology·Amelia L M Sutton, Paul N MacDonald
Jun 12, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Isabelle SiroisWendy E Ward
Jun 17, 2003·Clinical Endocrinology·Elena ZoicoOttavio Bosello
Dec 8, 2004·Hypertension·Kamal RahmouniAllyn L Mark
Jun 14, 2005·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·I T BonomoE G Moura
Nov 12, 2005·Bioscience Reports·Egberto Gaspar de Moura, Magna Cottini F Passos
Dec 7, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Cyrus CooperMark Hanson
Feb 7, 2007·The Journal of Endocrinology·Isabela Teixeira BonomoEgberto Gaspar de Moura
Mar 14, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Felix EcksteinEva-Maria Lochmüller
Oct 25, 2007·The Journal of Clinical Endocrinology and Metabolism·Bogdan GaluscaBruno Estour
Jan 17, 2008·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·E G MouraM C F Passos
May 8, 2008·Current Rheumatology Reports·Zoe A ColeCyrus Cooper
May 21, 2008·The Journal of Endocrinology·Isabela Teixeira BonomoEgberto Gaspar de Moura
Jun 21, 2008·International Journal of Biological Sciences·Hansjoerg HeepMarius von Knoch
Sep 11, 2008·Neuroimmunomodulation·E G de MouraM C F Passos
Jan 27, 2009·Acta Cirúrgica Brasileira·Ruy Garcia MarquesAndy Petroianu
Aug 13, 2009·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A T S FagundesP C Lisboa
Sep 9, 2009·The Journal of Physiology·Egberto Gaspar de MouraPatricia Cristina Lisboa

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Citations

Jan 7, 2017·Clinical and Experimental Pharmacology & Physiology·Nayara Peixoto-SilvaPatricia C Lisboa
Jun 4, 2020·Journal of Developmental Origins of Health and Disease·Luana Lopes SouzaPatricia Cristina Lisboa
Jun 11, 2020·Journal of Developmental Origins of Health and Disease·Iala Milene BertassoPatricia Cristina Lisboa
Jul 21, 2020·Journal of Developmental Origins of Health and Disease·Juliana LimaBianca Gregorio

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