Bone metabolism in spinal cord injured individuals and in others who have prolonged immobilisation. A review

Paraplegia
D UebelhartA Chantraine

Abstract

Immobilisation or disuse is a condition known to be associated with a decrease in bone mass, osteopenia and in some people leading to osteoporosis with an increased risk of fractures. In this condition, previous histomorphometric and biochemical reports have shown an uncoupling between bone formation and resorption, but the exact sequence of the events resulting in bone loss is still not fully understood. In spinal cord injury for instance, the main finding soon after the onset is decreased osteoblastic activity associated with a dramatic increase in bone degradation. The overall consequence of these metabolic events is the development of a rapid and severe osteoporosis only observed in the paralysed part of the body associated with the loss of biomechanical strength and the biosynthesis of a structurally modified matrix which is unable to sustain normal mechanical stress. This situation dramatically increases the risk of fractures. The same uncoupling phenomenon has been described in healthy individuals who have been submitted to long duration bedrest and also in astronauts during spaceflight; but the timing, intensity and the metabolic subset may be different as these people do recover after cessation of the disuse period, wh...Continue Reading

References

Feb 1, 1975·Journal of Chronic Diseases·J Claus-WalkerW A Spencer
Nov 1, 1992·The American Journal of Physiology·W H WeintraubT E Machen
Dec 8, 1992·Biochimica Et Biophysica Acta·G J RucklidgeS P Robins
Dec 1, 1992·European Journal of Clinical Investigation·B BätgeP K Müller
Dec 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L Vico, C Alexandre
Dec 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A I GrigorievL B Buravkova
May 1, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D E GarlandD A Weinstein
May 1, 1992·Paraplegia·V FinsenK J Fougner
Mar 1, 1992·Paraplegia·F K Judd, D J Brown
Jun 1, 1990·European Journal of Clinical Investigation·F Biering-SørensenO P Schaadt
Aug 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A D LeblancJ M Krebs
Aug 1, 1986·Calcified Tissue International·M D GrynpasD J Simmons
Aug 1, 1986·Calcified Tissue International·G L MechanicM Yamauchi
Nov 1, 1987·Calcified Tissue International·A LeBlancP Johnson
Aug 1, 1988·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D D Thompson, G A Rodan
Jan 1, 1986·Bone·D R YoungW S Jee
Feb 1, 1986·Endocrinology·R K GlobusE Morey-Holton
Jan 1, 1974·Calcified Tissue Research·P MinaireJ Bourret
Jan 1, 1984·Calcified Tissue International·V S Schneider, J McDonald
May 1, 1984·Calcified Tissue International·P MinaireP J Meunier
Jan 1, 1993·Connective Tissue Research·A J BaileyP W Thompson
Jun 1, 1963·The Journal of Clinical Investigation·F BRONNERJ R COBB

❮ Previous
Next ❯

Citations

Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H NorimatsuJ Li
Jul 29, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S-D JiangL-Y Dai
Oct 13, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S-D JiangL-Y Dai
Oct 10, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D LiuL-Y Dai
Dec 18, 2010·Calcified Tissue International·N CaseJ Rubin
Jul 9, 2013·European Radiology·Lorenzo NardoThomas M Link
Jan 12, 1999·The Veterinary Journal·O M LepageD Uebelhart
Dec 28, 1999·Public Health Nutrition·F Branca
Jan 3, 2006·Journal of Neurologic Physical Therapy : JNPT·Mark S Nash
Jun 14, 2006·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Lora M GiangregorioNeil McCartney
Aug 7, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Janet RubinW Robert Taylor
Jun 21, 2008·Journal of Rehabilitation Research and Development·Shauna Dudley-Javoroski, Richard K Shields
Aug 17, 2011·International Journal of General Medicine·Yannis Dionyssiotis
Oct 1, 2004·Sports Medicine·Patrick L Jacobs, Mark S Nash
Dec 14, 2011·Journal of Visualized Experiments : JoVE·Madonna M McManus, Raymond J Grill
Feb 13, 2002·The Journal of Orthopaedic and Sports Physical Therapy·Richard K Shields
Nov 5, 1998·Aging : Clinical and Experimental Research·M Sinaki
Nov 7, 2000·Assistive Technology : the Official Journal of RESNA·W M Grill, R F Kirsch
Oct 19, 2007·Developmental Neurorehabilitation·Anthony J W LiuMary-Clare A Waugh
Jun 7, 2008·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Yannis DionyssiotisGeorgios P Lyritis
Jan 30, 2008·Archives of Physical Medicine and Rehabilitation·William C LoganHelen M Hoenig
Apr 6, 2007·Medical Hypotheses·Michael W C PayneGuy Trudel
Apr 7, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J Ignacio AguirreTeresita Bellido
Jan 31, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Sylvain PicardPierre A Guertin
Oct 24, 2006·Clinical Endocrinology·Sheng-Dan JiangLi-Yang Dai
Sep 6, 2012·Journal of Cellular and Molecular Medicine·Jun YanLei-Sheng Jiang
Jul 3, 2013·International Journal for Numerical Methods in Biomedical Engineering·Pascal R BuenzliPeter Pivonka
Jan 29, 2011·Archives of Physical Medicine and Rehabilitation·Shauna Dudley-JavoroskiRichard K Shields
Jan 11, 2005·Archives of Physical Medicine and Rehabilitation·Jen-Wen HungJung-Fu Chen
Jul 29, 2004·Metabolism: Clinical and Experimental·Laurent MaïmounCharles Sultan
Nov 24, 1999·Archives of Physical Medicine and Rehabilitation·W O McKinleyM J DeVivo
Sep 28, 1998·Archives of Physical Medicine and Rehabilitation·A HartkoppF Biering-Sørensen
Oct 11, 2005·Archives of Physical Medicine and Rehabilitation·Richard K ShieldsVicki M Mattiace
Nov 26, 2010·Annals of Physical and Rehabilitation Medicine·C CharmetantP Calmels

❮ Previous
Next ❯

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