Bone metastases in germ cell tumor patients.

Journal of Cancer Research and Clinical Oncology
Karin OechsleFriedemann Honecker

Abstract

Little data exist on characteristics, treatment, and outcome of patients with bone metastases from germ cell cancer. A total of 434 patients with poor prognosis germ cell cancer, who underwent primary high-dose chemotherapy (HD-CTX) within two phase II trials, were retrospectively analyzed. 40 patients (9%) presented with primary bone metastases. Bone metastases were significantly more frequently observed in patients with primary mediastinal tumors, yolk sac tumor histology, and synchronous liver metastases. Overall response rate to HD-CTX was 85%. 20% of patients underwent consolidating radiotherapy, and 10% had resection of bone metastases revealing necrosis in all cases. Progression-free survival rate after primary treatment was 63% and, including salvage treatment after first relapse, overall long-term survival rate was 75%. Four patients (0.9%) relapsed with isolated bone metastases, all with bone metastases at primary diagnosis. None had previously received surgery or radiotherapy and all died within 1 year. 10 patients with primary bone metastases showed recurrences at other localizations. No patient relapsed with bone plus other metastases or with de novo bone metastases. Bone metastases were associated with a primary m...Continue Reading

References

Oct 1, 1988·British Journal of Urology·A K AsthanaM S Agrawal
Dec 1, 1988·British Journal of Cancer·R N HitchinsK D Bagshawe
Sep 1, 1985·Clinical Radiology·C H Collis, H Eckert
Jan 1, 1997·Clinical Oncology : a Journal of the Royal College of Radiologists·G M Mead, S P Stenning
Nov 5, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C BokemeyerC Nichols
Mar 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Lawrence H Einhorn
Mar 26, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C KollmannsbergerC Bokemeyer
Apr 22, 2006·European Urology·Ryan K BerglundEric A Klein
Dec 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jörg T HartmannUNKNOWN German Testicular Cancer Study Group

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Citations

Jun 26, 2013·BJU International·Mariam Jamal-HanjaniSimon Chowdhury
Jun 23, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Takahiro KojimaHiroyuki Nishiyama
Nov 30, 2014·Abdominal Imaging·Monica J WoodStephanie A Howard
Nov 15, 2014·Journal of Cancer Research and Clinical Oncology·Christoph OingKarin Oechsle
Apr 11, 2014·The Oncologist·Stephen B RiggsDerek Raghavan
Aug 17, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F HoneckerA Horwich
Dec 21, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C OingC Bokemeyer

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