Bone metastases in thyroid cancer

Journal of Bone Oncology
Nicole M Iñiguez-ArizaBart L Clarke

Abstract

Whereas preemptive screening for the presence of lymph node and lung metastases is standard-of-care in thyroid cancer patients, bone metastases are less well studied and are often neglected in thyroid cancer patient surveillance. Bone metastases in thyroid cancer are, however, independently associated with poor/worse prognosis with a median overall survival from detection of only 4 years despite an otherwise excellent prognosis for the vast majority of thyroid cancer patients. In this review we summarize the state of current knowledge as pertinent to bony metastatic disease in thyroid cancer, including clinical implications, impacts on patient function and quality of life, pathogenesis, and therapeutic opportunities, proposing approaches to patient care accordingly. In particular, bone metastasis pathogenesis appears to reflect cooperatively between cancer and the bone microenvironment creating a "vicious cycle" of bone destruction rather than due exclusively to tumor invasion into bone. Additionally, bone metastases are more frequent in follicular and medullary thyroid cancers, requiring closer bone surveillance in patients with these histologies. Emerging data also suggest that treatments such as multikinase inhibitors (MKIs)...Continue Reading

References

Jul 1, 1978·British Journal of Cancer·J L HaywardA Segaloff
Mar 1, 1977·British Journal of Cancer·J L HaywardR D Rubens
Jan 24, 1974·The New England Journal of Medicine·J A Gottlieb, C S Hill
Sep 9, 1999·Radiology·E M MaromE F Patz
Jan 26, 2000·Thyroid : Official Journal of the American Thyroid Association·J D LinY S Ho
Apr 25, 2000·Thyroid : Official Journal of the American Thyroid Association·A G PittasR J Robbins
Jul 18, 2000·Cancer·F W OrrG Singh
Aug 25, 2000·Thyroid : Official Journal of the American Thyroid Association·K M van TolT P Links
Mar 29, 2001·Thyroid : Official Journal of the American Thyroid Association·K T ChenE C Chan
Apr 12, 2001·The Journal of Clinical Endocrinology and Metabolism·M O BernierG Hejblum
Aug 4, 2001·Thyroid : Official Journal of the American Thyroid Association·H SchirrmeisterS N Reske
May 25, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Lioe-Fee de Geus-OeiEric P Krenning
Aug 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Isabelle PécheurPhilippe Clézardin
Aug 22, 2002·Nature Reviews. Cancer·Jean Paul Thiery
Jul 5, 2003·The Journal of Clinical Endocrinology and Metabolism·C F A Eustatia-RuttenJ W A Smit
Sep 23, 2003·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Isis GayedDonald Podoloff
Nov 5, 2003·Acta Oncologica·Ursula FalkmerEva Cavallin-Ståhl
Nov 6, 2003·Clinical Orthopaedics and Related Research·Deborah A Frassica
Jan 13, 2004·The Journal of Clinical Endocrinology and Metabolism·Bennett B ChinPaul Ladenson
Apr 16, 2004·The New England Journal of Medicine·G David Roodman
Jul 3, 2004·European Radiology·L S FreudenbergW Brandau
Jul 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tsuyoshi HamaokaNaoto T Ueno
Mar 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Norio KohnoShigemitsu Takashima
Apr 20, 2005·Skeletal Radiology·Laura M FayadElliot K Fishman
Jun 1, 2005·The Lancet Oncology·Ilora G FinlayMike Shelley
Jun 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sten NilssonOyvind S Bruland
Jun 28, 2005·Critical Reviews in Oncology/hematology·Giovanni Selvaggi, Giorgio V Scagliotti
Nov 22, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiao-Min YuJohn M Luk
Sep 5, 2006·European Radiology·Gerwin P SchmidtAndrea Baur-Melnyk
Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anke J RoelofsMichael J Rogers
May 17, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Shinji ItoShinji Naganawa
Aug 4, 2007·Endocrinology and Metabolism Clinics of North America·Jason A Wexler, John Sharretts

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Citations

Aug 4, 2020·Journal of Endocrinological Investigation·A NervoE Arvat
Jul 23, 2020·Journal of Endocrinological Investigation·M CelliniG Mazziotti
Dec 12, 2020·Annals of Medicine and Surgery·Suwardjo SuwardjoSumadi Lukman Anwar
Mar 9, 2021·Endocrinology and Metabolism·Sun Wook Cho, Young Joo Park
Apr 5, 2021·Seminars in Cancer Biology·Jes Sloth MathiesenUlla Feldt-Rasmussen
May 25, 2021·Clinical Case Reports·Thanh D HoangMohamed K M Shakir
Jul 21, 2021·Seminars in Cell & Developmental Biology·Charlotte Owen-Woods, Anjali Kusumbe
Sep 29, 2021·Laryngo- rhino- otologie·Konstantinos MantsopoulosHeinrich Iro

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Methods Mentioned

BETA
Transfection
sedation
GTPase

Clinical Trials Mentioned

NCT02390934

Software Mentioned

Medstar

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