Bone metastasis from a granulosa cell tumor of the ovary

Gynecologic Oncology
J Dubuc-LissoirG Allaire

Abstract

Granulosa cell tumors (GCT) of the ovary generally have a good prognosis. Recurrences tend to be late and are usually abdominopelvic. Bone metastases are extremely rare. A case of recurrent GCT with vertebral metastasis is presented. Radiologic studies were helpful in documenting the presence of an invasive tumor destroying the vertebral body of T7. Bone scintigraphy excluded other metastatic sites. Diagnosis could not be established by CT-scan-directed fine-needle aspiration cytology or trocar biopsies. Since the lesion was isolated and resectable, aggressive surgery with complete tumoral excision was performed followed by local radiation therapy. Megestrol acetate was given as systemic treatment. Multiple treatments of GCT may alter the pattern of recurrence. Every symptom should be thoroughly evaluated. Bone metastases may be treated aggressively.

References

Mar 30, 1999·Gynecologic Oncology·J K WolfD M Gershenson
Apr 8, 2000·European Journal of Endocrinology·G M Lambert-Messerlian
Mar 1, 1995·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·D. TresukosolJ.J. Kavanagh
Sep 1, 1961·Clinical Obstetrics and Gynecology·H L KOTTMEIER

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Citations

Mar 22, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A AuranenS Grénman
Dec 22, 2011·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·L GottwaldA Cialkowska-Rysz
Mar 14, 2008·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·C Van HolsbekeD Timmerman
May 9, 2006·Diagnostic Cytopathology·Nalini GuptaSarala Malhotra
Aug 1, 2015·Acta Obstetricia Et Gynecologica Scandinavica·Hannah S van MeursLuc R C W van Lonkhuijzen
Jun 23, 2009·Journal of Korean Medical Science·Hyun Jung KimHee Sook Park
Apr 10, 2014·Gynecologic Oncology·Hannah S van MeursMarrije R Buist
Jul 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicoletta ColomboAlessandra Insinga
Jan 25, 2003·Current Opinion in Obstetrics & Gynecology·Gavin C E Stuart, Lesa M Dawson
Jun 5, 2020·Surgical Case Reports·Itsuki KoganezawaShigeyuki Kawachi

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