Bone metastasis pattern in initial metastatic breast cancer: a population-based study

Cancer Management and Research
Zhenchong XiongXi Wang

Abstract

Bone is one of the most common sites of breast cancer metastasis, and population-based studies of patients with bone metastasis in initial metastatic breast cancer (MBC) are lacking. From 2010 to 2013, 245,707 breast cancer patients and 8901 patients diagnosed with initial bone metastasis were identified by Surveillance, Epidemiology, and End Results database of the National Cancer Institute. Multivariate logistic and Cox regression were used to identify predictive factors for the presence of bone metastasis and prognosis factors. Kaplan-Meier method and log-rank test were used for survival analysis. Eight thousand nine hundred one patients with initial MBC had bone involvement, accounting for 3.6% of the entire cohort and 62.5% of the patients with initial MBC. Also, 70.5% of patients with bone metastasis were hormone receptor (HR) positive (HR+/human epidermal growth factor receptor 2 [HER2]-: 57.6%; HR+/HER2+: 12.9%). Patients with initial bone metastasis had a better 5-year survival rate compared to those with initial brain, liver, or lung metastasis. HR+/HER2- and HR+/HER2+ breast cancer had a propensity of bone metastasis in the entire cohort and were correlated with better prognosis in patients with initial bone metastas...Continue Reading

Citations

Jan 9, 2019·International Journal of Colorectal Disease·Xu GuoXin Wang
May 26, 2018·Cancers·Takahiro Kimura
Mar 5, 2019·Breast Cancer : Basic and Clinical Research·Akram YazdaniHedieh Zabolinezhad
Aug 11, 2020·Expert Review of Anticancer Therapy·Chandi C Mandal
Sep 12, 2018·BMC Cancer·Zhenchong XiongXi Wang
Jan 21, 2021·Cancer Management and Research·Zhen HuangChangyuan Wei
Jun 3, 2021·Cancers·Nico Hinz, Manfred Jücker

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