Bone microarchitecture and bone turnover in hepatic cirrhosis.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
R WakolbingerP Pietschmann

Abstract

Liver cirrhosis leads to bone loss. To date, information on bone quality (three-dimensional microarchitecture) and, thus, bone strength is scarce. We observed decreased bone quality at both assessed sites, independent of disease severity. Therefore, all patients should undergo early-stage screening for osteoporosis. Recent studies found low bone mineral density in cirrhosis, but data on bone microstructure are scarce. This study assessed weight-bearing and non-weight-bearing bones in patients with cirrhosis and healthy controls. The primary objective was to evaluate trabecular and cortical microarchitecture. This was a single-center study in patients with recently diagnosed hepatic cirrhosis. Thirty-two patients and 32 controls participated in this study. After determining the type of cirrhosis, the parameters of bone microarchitecture were assessed by high-resolution peripheral quantitative computed tomography. Both cortical and trabecular microarchitectures showed significant alterations. At the radius, trabecular bone volume fraction was 17% lower (corrected p = 0.028), and, at the tibia, differences were slightly more pronounced. Trabecular bone volume fraction was 19% lower (p = 0.024), cortical bone mineral density 7% (p ...Continue Reading

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Citations

Jan 9, 2020·Wiener klinische Wochenschrift·Robert WakolbingerPeter Pietschmann
Jun 25, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J JadzicD Djonic
Apr 2, 2021·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Preyander ThakurThomas V Paul
Aug 24, 2021·Transplantation Proceedings·Erika Faride Rodríguez-AguilarIgnacio García-Juárez

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Methods Mentioned

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biopsies
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R
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