Bone microarchitecture of the calcaneus and its changes in aging: a histomorphometric analysis of 60 human specimens

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Martin RupprechtMichael Amling

Abstract

Bone structure and quality are an important parameter in the propensity of bone to fracture. Although the calcaneus is used as diagnostic reference site for osteoporosis by ultrasound, its structure has never been analyzed in detail. The purpose of this study was therefore to histomorphometrically analyze the trabecular microarchitecture of the calcaneus, and to determine whether the calcaneal bone structure is changing with age. Sixty complete human calcanei were harvested from thirty age- and gender-matched patients at autopsy. Each of the three different age groups (group I: 20 to 40, group II: 41 to 60, group III: 61 to 80 years of age) was represented by 20 specimens. The specimens were subjected to radiographic, microCT, and histologic analysis. Bone structure and bone mass of the calcaneus were quantified for three different regions of interest: the anterior ROI, the superior ROI (the subtalar region under the posterior facet), and the posterior ROI. An iliac crest biopsy was obtained from all patients to exclude any metabolic bone disease. Histomorphometric analysis revealed significant differences in bone volume within the calcaneus with highest values in the superior ROI: age group I: 31.3% (27.8-34.8%); II: 25.5% (22...Continue Reading

References

Jan 1, 1992·Journal of Orthopaedic Trauma·R Sanders
Dec 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M ParfittR R Recker
Jun 26, 1986·The New England Journal of Medicine·B L Riggs, L J Melton
May 1, 1982·Calcified Tissue International·G A Rodan, T J Martin
Mar 1, 1993·The Journal of Bone and Joint Surgery. American Volume·D Paley, H Hall
Mar 1, 1993·The Journal of Bone and Joint Surgery. British Volume·D M EastwoodR M Atkins
Jan 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M AmlingG Delling
Mar 5, 1998·The Journal of Bone and Joint Surgery. American Volume·A Miric, B M Patterson
Aug 6, 1998·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J C LinS Majumdar
Dec 22, 1999·European Radiology·T M LinkJ E Adams
Feb 22, 2000·The Journal of Bone and Joint Surgery. American Volume·R Sanders
Jun 27, 2002·Zeitschrift für Orthopädie und ihre Grenzgebiete·J AndermahrK E Rehm
Jun 28, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E LespessaillesC L Benhamou
Feb 1, 1953·The Journal of Bone and Joint Surgery. British Volume·C K WARRICK, A E BREMNER
Nov 19, 2003·The Medical Clinics of North America·Sue A Brown, Clifford J Rosen
Dec 17, 2003·Journal of Orthopaedic Trauma·Julian M AldridgeJames A Nunley
Jan 22, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A M SchottP J Meunier
Mar 1, 1952·The British Journal of Surgery·P ESSEX-LOPRESTI
Apr 8, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Claus C GlüerSami Kolta
Jun 10, 2004·Clinical Orthopaedics and Related Research·Kazuo ItoHideji Kura
Jul 9, 2004·Clinical Orthopaedics and Related Research·Pia PogodaMichael Amling

❮ Previous
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Citations

Nov 17, 2009·Calcified Tissue International·Matthias GebauerMichael Amling
May 16, 2008·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Songlin PengLing Qin
Nov 23, 2006·Current Osteoporosis Reports·Glenn A Ladinsky, Felix W Wehrli
Feb 12, 2009·The Journal of the Acoustical Society of America·G HaïatS Naili
Dec 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ashley W PalmerMarc E Levenston
Sep 15, 2012·Ultrasound in Medicine & Biology·Wei LinYi-Xian Qin
Apr 28, 2009·Ultrasound in Medicine & Biology·Kam-Fai TamKwok-Sui Leung
Jan 22, 2008·Journal of Human Evolution·Richard A LazenbyBenedikt Hallgrímsson
Dec 26, 2007·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Tamara J VokesMaryellen L Giger
Mar 14, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Felix EcksteinEva-Maria Lochmüller
Apr 26, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Weixi ZhangXing-Ming Shi
Jul 31, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Eva-Maria LochmüllerFelix Eckstein
Nov 6, 2012·Arthritis and Rheumatism·Merry Z C RuanBrendan H L Lee
Oct 28, 2010·American Journal of Physical Anthropology·Richard A LazenbyJean-Jacques Hublin
Mar 19, 2014·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Stephen J MacleanCraig A Cunningham
Nov 7, 2008·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·G RenaudM Defontaine
Nov 22, 2018·American Journal of Physical Anthropology·Jaap P P SaersJay T Stock
Nov 21, 2008·Journal of Anatomy·Craig A Cunningham, Sue M Black
Jul 31, 2013·Clinical Orthopaedics and Related Research·Matthias KrauseFlorian Barvencik

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