Bone microarchitecture of the tibial plateau in skeletal health and osteoporosis

The Knee
Matthias KrauseKarl-Heinz Frosch

Abstract

Impaired bone structure poses a challenge for the treatment of osteoporotic tibial plateau fractures. As knowledge of region-specific structural bone alterations is a prerequisite to achieving successful long-term fixation, the aim of the current study was to characterize tibial plateau bone structure in patients with osteoporosis and the elderly. Histomorphometric parameters were assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT) in 21 proximal tibiae from females with postmenopausal osteoporosis (mean age: 84.3 ± 4.9 years) and eight female healthy controls (45.5 ± 6.9 years). To visualize region-specific structural bony alterations with age, the bone mineral density (Hounsfield units) was additionally analyzed in 168 human proximal tibiae. Statistical analysis was based on evolutionary learning using globally optimal regression trees. Bone structure deterioration of the tibial plateau due to osteoporosis was region-specific. Compared to healthy controls (20.5 ± 4.7%) the greatest decrease in bone volume fraction was found in the medio-medial segments (9.2 ± 3.5%, p < 0.001). The lowest bone volume was found in central segments (tibial spine). Trabecular connectivity was severely reduced. Import...Continue Reading

Citations

Mar 20, 2019·Operative Orthopädie und Traumatologie·M KrauseK-H Frosch
Feb 4, 2021·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Christopher E KeenSteven K Boyd
Dec 11, 2020·Cells·Natividad Alcorta-SevillanoClara I Rodríguez
Jul 17, 2021·Archives of Orthopaedic and Trauma Surgery·L ThoreauE Thienpont
Oct 14, 2021·Surgical and Radiologic Anatomy : SRA·Shi-Zhu SunHong-Jin Sui

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