Bone mineral changes in young women with hypothalamic amenorrhea treated with oral contraceptives, medroxyprogesterone, or placebo over 12 months

American Journal of Obstetrics and Gynecology
A C HergenroederK Ellis

Abstract

The objectives of this study were to assess (1) whether treatment with oral contraceptives, in comparison with medroxyprogesterone and placebo, improved bone mineral in women with hypothalamic amenorrhea and (2) whether treatment with medroxyprogesterone, in comparison with placebo, improved bone mineral in women with hypothalamic oligomenorrhea. The study was a randomized, controlled clinical trial. Twenty-four white women, aged 14 to 28 years, with hypothalamic amenorrhea or oligomenorrhea were prospectively enrolled for a 12-month intervention period. Amenorrheic subjects were randomized to receive oral contraceptives, medroxyprogesterone, or placebo. Oligomenorrheic subjects were randomized to receive medroxyprogesterone or placebo. Bone mineral was measured by dual-energy x-ray absorptiometry at baseline and at 6 and 12 months. In amenorrheic subjects spine and total body bone mineral measurements at 12 months were greater in the oral contraceptive group than in the medroxyprogesterone and placebo groups when baseline bone mineral measurements, body weight, and age were controlled for (p < or = 0.05). There were no differences in hip bone mineral calcium and bone mineral density measurements at 12 months among the three gr...Continue Reading

References

Mar 1, 1991·The Journal of Clinical Endocrinology and Metabolism·L K BachrachR Marcus
Apr 1, 1991·The Journal of Clinical Endocrinology and Metabolism·M P WarrenW G Hamilton
Jan 1, 1990·Bone·K M DaviesR R Recker
Mar 1, 1988·Radiology·V GilsanzC C Cann
Aug 2, 1984·The New England Journal of Medicine·B L DrinkwaterM B Southworth

❮ Previous
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Citations

Mar 13, 2014·British Journal of Sports Medicine·Margo MountjoyArne Ljungqvist
Jan 9, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J D VescoviM J De Souza
May 10, 2003·Journal of Women's Health·Catherine M Gordon
Aug 18, 1999·British Journal of Sports Medicine·K BennellK Crossley
Jun 1, 1999·Comprehensive Therapy·J W Greene
Apr 15, 2008·Reviews in Endocrine & Metabolic Disorders·Madhusmita Misra
May 12, 2011·Reviews in Endocrine & Metabolic Disorders·Michelle M Isley, Andrew M Kaunitz
Mar 29, 2013·Current Reviews in Musculoskeletal Medicine·Yin-Ting ChenMichael Fredericson
May 20, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Hawley Almstedt Shoepe, Christine M Snow
Dec 17, 2009·Journal of Bone and Mineral Metabolism·Marrissa Martyn-St James, Sean Carroll
Apr 6, 2001·Journal of the Society of Pediatric Nurses : JSPN·J H Kass-Wolff
Jan 21, 2000·Pharmacotherapy·J P Lambert
Nov 6, 2010·Journal of Osteoporosis·Vanadin Seifert-Klauss, Jerilynn C Prior
Dec 13, 2003·Maturitas·Jos H H Thijssen
Jun 12, 2010·Pediatric Clinics of North America·Donald E GreydanusHelen D Pratt
Feb 24, 2009·Primary Care·Diana L Heiman
Aug 2, 2008·Journal of Pediatric and Adolescent Gynecology·Cynthia Holland HallSarah L Stevens
Nov 9, 2011·Journal of Midwifery & Women's Health·Joyce King
Apr 8, 2009·The International Journal of Eating Disorders·Leslie A SimVictor M Montori
Apr 22, 2006·Contraception·Summer L MartinsAnna F Glasier
Mar 31, 2000·Clinics in Sports Medicine·C F SanbornK I Dieringer
Nov 25, 2000·Obstetrics and Gynecology Clinics of North America·J T Jensen, L Speroff
Jun 25, 2008·Annals of the New York Academy of Sciences·Michelle P Warren, Abigail T Chua
Jul 17, 2014·Best Practice & Research. Clinical Obstetrics & Gynaecology·Monica V Dragoman
Apr 4, 2017·The Journal of Clinical Endocrinology and Metabolism·Catherine M GordonMichelle P Warren
Feb 8, 2002·Pediatric Annals·Ronald A Feinstein, Teri Metcalf McCambridge
Sep 28, 2012·Sports Health·Taraneh Gharib Nazem, Kathryn E Ackerman
Jan 25, 2012·Nature Reviews. Endocrinology·Madhusmita Misra
Jul 3, 2004·Human Reproduction Update·Mary Jane De Souza, Nancy I Williams
Oct 3, 2007·Medicine and Science in Sports and Exercise·Aurelia NattivUNKNOWN American College of Sports Medicine
Dec 12, 2001·Sports Medicine·D C Cumming, C E Cumming
Oct 26, 2000·Sports Medicine·M Burrows, S Bird
Jul 20, 2005·Treatments in Endocrinology·Marco GambaccianiAndrea R Genazzani
Oct 1, 2002·The Physician and Sportsmedicine·Michelle P WarrenEmily M Bronson
Jan 22, 2005·Current Sports Medicine Reports·Mary Jane De Souza, Nancy I Williams
Oct 12, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kathryn E AckermanMadhusmita Misra
Jan 7, 2004·Medicine and Science in Sports and Exercise·Cathy L ZankerHoward S Jacobs
Jun 22, 2011·Sports Medicine·Gaele DucherMary Jane De Souza
Jun 7, 2002·The Journal of Clinical Endocrinology and Metabolism·Becky A KaufmanRichard N Pierson

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