Bone mineral content in the senescent rat femur: an assessment using single photon absorptiometry

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
G M KiebzakB Sacktor

Abstract

The single photon absorptiometry technique was evaluated for measuring bone mineral content (BMC) of the excised femurs of the rat, and the system was used to examine the changes in cortical and trabecular bone from young adult (6 mo), mature adult (12 mo), and senescent (24 mo) male and female animals. BMC of the femur midshaft, representing cortical bone, apparently increased progressively with advancing age. The width of the femur at the scan site also increased with age. Normalizing the midshaft BMC by width partially compensated for the age-associated increase. However, when bone mineral values were normalized by the cortical area at the scan site, to take into account the geometric differences in the femurs of different aged animals, maximum bone densities were found in the mature adult and these values decreased slightly in the femurs from senescent rats. In contrast, the BMC of the femur distal metaphysis, representing trabecular bone, decreased markedly in the aged rat. The loss of trabecular bone was also evident from morphological examination of the distal metaphysis. These findings indicated that bone mineral loss with age was site specific in the rat femur. These studies provided additional evidence that the rat mi...Continue Reading

References

Feb 1, 1988·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G M KiebzakB Sacktor
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Citations

Jan 1, 1991·Experimental Gerontology·G M Kiebzak
Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·P K ChakrabortyA S Mitchell
Jun 12, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R A MeyerG M Kiebzak
Aug 1, 1988·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G M KiebzakB Sacktor
Jul 14, 2012·Arquivos brasileiros de endocrinologia e metabologia·Claudia Cardoso NettoMário Roberto Maróstica
Jan 1, 1992·Journal of Applied Biomaterials : an Official Journal of the Society for Biomaterials·Y IwashitaT Kokubo
Jul 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M G GriffinR Pacifici
Jun 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M KawaseT Matsuo
Feb 1, 1990·Calcified Tissue International·D B Kimmel, T J Wronski

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