Bone mineral density, adiposity, and cognitive functions

Frontiers in Aging Neuroscience
Hamid R SohrabiR N Martins

Abstract

Cognitive decline and dementia due to Alzheimer's disease (AD) have been associated with genetic, lifestyle, and environmental factors. A number of potentially modifiable risk factors should be taken into account when preventive or ameliorative interventions targeting dementia and its preclinical stages are investigated. Bone mineral density (BMD) and body composition are two such potentially modifiable risk factors, and their association with cognitive decline was investigated in this study. 164 participants, aged 34-87 years old (62.78 ± 9.27), were recruited for this longitudinal study and underwent cognitive and clinical examinations at baseline and after 3 years. Blood samples were collected for apolipoprotein E (APOE) genotyping and dual energy x-ray absorptiometry (DXA) was conducted at the same day as cognitive assessment. Using hierarchical regression analysis, we found that BMD and lean body mass, as measured using DXA were significant predictors of episodic memory. Age, gender, APOE status, and premorbid IQ were controlled for. Specifically, the List A learning from California Verbal Learning Test was significantly associated with BMD and lean mass both at baseline and at follow up assessment. Our findings indicate t...Continue Reading

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Citations

Jan 7, 2016·Frontiers in Aging Neuroscience·Manuel Menéndez-González, Tania Álvarez-Avellón
Nov 3, 2016·Age and Ageing·Steven BradburnChris Murgatroyd
Sep 14, 2019·International Journal of Molecular Sciences·Michela RossiAndrea Del Fattore
Jun 12, 2019·Connective Tissue Research·Gabrielle FrameChristine M Dengler-Crish
May 16, 2020·The International Journal of Neuroscience·Misa NakamuraMasatoshi Takeda
Nov 28, 2019·Aging Clinical and Experimental Research·Antonino CatalanoNunziata Morabito
Jan 5, 2021·Frontiers in Nutrition·Silvia FostinelliStefano F Cappa
Jan 12, 2021·Frontiers in Psychology·Ryan R KellyAmanda C LaRue

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Methods Mentioned

BETA
X-ray

Software Mentioned

CAMCOG
SPSS
Excel
R

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