Bone mineral density and bone metabolism in children treated for bone sarcomas

Pediatric Research
Elena RuzaAna Patiño-Garcia

Abstract

In adolescent bone sarcoma patients, bone mass acquisition is potentially compromised at a time in which it should be at a maximum. To evaluate the problem we measured bone mineral density (BMD) and serum markers of bone formation and resorption in a series of pediatric patients with bone tumors. BMD was measured by dual-energy x-ray absorptiometry, at clinical remission, for lumbar spine and the neck of the femur in 38 osteosarcoma and 25 Ewing's sarcoma patients. Mean age was 20.65 and 19.13 y respectively. Serum markers of bone metabolism were: OC, PICP, ICTP, 25-OH vit D and 1,25-(OH)(2) vit D, IGF-I, IGFBP-3 and intact PTH. Serum was sampled throughout anti-tumoral treatments and follow-up. We analyzed 85 samples from 59 osteosarcoma patients and 54 samples from 36 Ewing's sarcoma patients. Patients had decreased lumbar and femoral BMD. The decrease was more pronounced in pubertal patients compared with those who had completed pubertal development at the time of disease diagnosis. Multivariate analysis indicated that sex, age, weight and BMI were significant in lumbar BMD depletion. Weight and BMI were significant in femoral BMD depletion. Serum markers of bone formation (PICP and OC) and resorption (ICTP) were, throughout...Continue Reading

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Citations

Apr 14, 2007·Pediatric Radiology·Larry A BinkovitzMaria J Henwood
Jul 3, 2008·Pediatric Radiology·Larry A BinkovitzPaul Sparke
May 17, 2012·Clinical Sarcoma Research·Yulia A SavitskayaJosé Clemente Ibarra-Ponce de León
Jul 13, 2014·Clinical Orthopaedics and Related Research·Gerhard M HobuschGerold Holzer
Feb 18, 2016·Clinical Orthopaedics and Related Research·Gerhard M HobuschGerold Holzer
Oct 9, 2007·Advances in Pediatrics·Jill SimmonsJoel Steelman
Jun 5, 2007·Seminars in Nuclear Medicine·Larry A BinkovitzPaul Sparke
Nov 19, 2010·Advances in Medical Sciences·J AmbroszkiewiczW Woźniak
May 12, 2018·Journal of Pediatric Endocrinology & Metabolism : JPEM·Veronica C P de MeloCarlos E Dos S Ferreira
Dec 8, 2007·Pediatric Blood & Cancer·Inge M van der Sluis, Marry M van den Heuvel-Eibrink
Apr 23, 2016·Annals of Pediatric Endocrinology & Metabolism·Se Won LimJung Sub Lim
Jul 20, 2011·Current Opinion in Supportive and Palliative Care·Rebecca Silbermann, G David Roodman
Jul 19, 2012·Clinical Orthopaedics and Related Research·Ulrike Michaela Pirker-FrühaufAndreas Leithner
Oct 6, 2020·Annals of Pediatric Endocrinology & Metabolism·Hye Young Jin, Jun Ah Lee
Jun 9, 2021·Cancer Medicine·Jenneke E van AtteveldSebastian J C M M Neggers

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