Bone mineral density and bone metabolism of prepubertal children with asthma after long-term treatment with inhaled corticosteroids

Pediatric Pulmonology
A M BootS M de Muinck Keizer-Schrama

Abstract

Little is known about the effect of long-term treatment with inhaled corticosteroids (ICS) on bone mineral density (BMD) in asthmatic children. In the present cross-sectional study BMD, bone metabolism, height, body composition, and bone age were evaluated in 40 prepubertal children (21 boys) with asthma, treated with a moderate to high dose of ICS over a period of 3 to 8 years. Body composition and BMD of the lumbar spine and total body were measured by Dual Energy X-ray Absorptiometry. BMD results were compared with 148 prepubertal healthy children of the same population. Blood samples were taken for the determination of biochemical bone parameters. The asthmatic children had decreased height, lean tissue mass and fat mass, and a delay of bone maturation, indicating growth retardation. ICS-treated asthma was negatively correlated with total body BMD in a multiple regression model with adjustment for age, gender, height and weight (P = 0.01). Duration of ICS therapy correlated negatively with total body BMD when it was added to the model (P = 0.01). Lumbar spine BMD was not affected by ICS in children with ICS-treated asthma. If age of the asthmatic children was replaced by their bone age in the model, no significant correlati...Continue Reading

References

Mar 1, 1977·The Journal of Allergy and Clinical Immunology·R HauspieF Alexander
Jul 6, 1991·Lancet·P RustinA Munnich
Jul 6, 1991·Lancet·S TeelucksinghP R Holt
Feb 27, 1992·The New England Journal of Medicine·J S FinkelsteinA Klibanski
Jul 20, 1991·BMJ : British Medical Journal·O D Wolthers, S Pedersen
Oct 1, 1991·The Journal of Allergy and Clinical Immunology·J H ToogoodL J Fraher
Oct 19, 1991·BMJ : British Medical Journal·M A HansenC Christiansen
Mar 16, 1991·BMJ : British Medical Journal·E M PouwE Endert
Nov 1, 1990·The Journal of Clinical Endocrinology and Metabolism·S M Ott
Mar 1, 1990·Annals of Internal Medicine·B P Lukert, L G Raisz
Feb 1, 1988·Baillière's Clinical Endocrinology and Metabolism·T J MartinG C Nicholson
Oct 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M ParfittS M Krane
Aug 4, 1983·The New England Journal of Medicine·A D Adinoff, J R Hollister
Sep 1, 1981·Acta paediatrica Scandinavica·A J MartinP D Phelan
Nov 1, 1995·The Journal of Allergy and Clinical Immunology·N A HananiaS Kesten
Feb 1, 1995·The Journal of Pediatrics·S CrowleyC G Brook
Nov 1, 1994·The Journal of Allergy and Clinical Immunology·L P BouletJ Brown
Sep 1, 1994·The Journal of Allergy and Clinical Immunology·K A KinbergJ C Gallagher
Dec 2, 1993·The New England Journal of Medicine·B VolovitzI Varsano
Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·L C MartinatiA L Boner
Sep 1, 1995·Pediatric Pulmonology·R J HoppG C Gallagher
Aug 1, 1997·The American Journal of Clinical Nutrition·A M BootS M de Muinck Keizer-Schrama

❮ Previous
Next ❯

Citations

Dec 25, 2010·Calcified Tissue International·Eftichia KorakakiChristina Giannakopoulou
Apr 14, 2007·Pediatric Radiology·Larry A BinkovitzMaria J Henwood
Jul 3, 2008·Pediatric Radiology·Larry A BinkovitzPaul Sparke
Apr 21, 2007·Journal of Bone and Mineral Metabolism·Eftichia KorakakiChristina Giannakopoulou
Mar 17, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·E O Meltzer
Dec 26, 2001·Current Opinion in Pulmonary Medicine·Conroy A WongPaul M Casey
Feb 27, 2009·Current Opinion in Pediatrics·Ljiljana BogunovicMaria G Vogiatzi
Aug 9, 2007·Epilepsia·Raj D ShethBruce P Hermann
Dec 19, 2001·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·P GeusensS van der Linden
Mar 3, 2009·Clinical Medicine & Research·John L FaulWare G Kuschner
Oct 7, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P König, C F Grigg
Jun 5, 2007·Seminars in Nuclear Medicine·Larry A BinkovitzPaul Sparke
Feb 10, 2007·Rheumatic Diseases Clinics of North America·Jean-Pierre Devogelaer
May 30, 2006·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Christine M SmithRichard Eastell
Apr 21, 2012·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Zarqa AliCharlotte Suppli Ulrik
Jun 18, 2010·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Wei ZhouUNKNOWN CaMos Research Group
Aug 24, 2016·The World Allergy Organization Journal·Elham HossnyPeter Le Souef
Jan 12, 2000·The Annals of Pharmacotherapy·K V Blake
Aug 23, 2001·Journal of Pediatric Endocrinology & Metabolism : JPEM·I M van der Sluis, S M de Muinck Keizer-Schrama
Mar 16, 2017·Paediatric Drugs·Yujuan Zhang, Diana Milojevic
May 7, 2002·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Nerin N BahcecilerMujdat M Basaran
Oct 22, 2002·American Journal of Physiology. Endocrinology and Metabolism·Nansie A McHughJohn A Hey
Nov 4, 2000·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·G JonesA Carmichael
Apr 4, 2021·Nutrients·Jacob T MeyAnny Mulya
Feb 6, 2002·Pediatric Clinics of North America·Mary B Leonard, Babette S Zemel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

American Journal of Respiratory and Critical Care Medicine
L Agertoft, S Pedersen
Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
T C M de CastroM O E Hilário
Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
T C M de CastroM O E Hilário
© 2021 Meta ULC. All rights reserved