Bone mineral density and its determinants in diabetes: the Fremantle Diabetes Study

Diabetologia
V RakicT M E Davis

Abstract

We assessed the effects of type 1 and type 2 diabetes on bone density and metabolism. We analysed bone mineral density (BMD) measured at the hip, spine and forearm using dual energy X-ray absorptiometry in 34 patients with type 1 and 194 patients with type 2 diabetes. Patients were from the community-based Fremantle Diabetes Study, and findings for them were compared with those from normal age- and sex-matched control subjects from the local community. Biochemical and hormonal markers of bone metabolism were measured in a subset of 70 patients. After adjusting for age and BMI, there was a lower BMD at total hip (p<0.001) and femoral neck (p=0.012) in type 1 men vs control subjects, but type 1 women and matched controls had similar BMD at each site. There was a higher BMD at total hip (p=0.006), femoral neck (p=0.026) and forearm (p<0.001) in type 2 women vs control subjects, but diabetes status was not associated with BMD in type 2 men after adjustment for age and BMI. Serum oestradiol, BMI, C-terminal telopeptide of collagen type 1 and male sex were consistently and independently associated with BMD at forearm, hip and femoral neck and explained 61, 55 and 50% of the total variance in BMD, respectively, at these sites. Spine B...Continue Reading

References

Jan 29, 1976·The New England Journal of Medicine·M E LevinL V Avioli
Dec 16, 1992·JAMA : the Journal of the American Medical Association·E Barrett-Connor, T L Holbrook
May 1, 1990·Journal of Internal Medicine·B MathiassenP Rødbro
Nov 1, 1985·Diabetic Medicine : a Journal of the British Diabetic Association·T F CundyP J Watkins
Sep 4, 1980·The New England Journal of Medicine·H HeathC P Chu
Jul 1, 1994·Bone and Mineral·J M OlmosJ González-Macías
Jun 1, 1993·American Journal of Epidemiology·H E MeyerJ A Falch
Dec 1, 1996·Diabetes Care·E Barrett-Connor, D Kritz-Silverstein
Feb 28, 1998·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·B PiepkornJ Beyer
Dec 16, 1998·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T Miazgowski, S Czekalski
Dec 16, 1998·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C G Smeets-GoevaersV J Pop
Jul 2, 1999·Diabetes Care·J T TuominenT Rönnemaa
Oct 16, 1999·The Journal of Clinical Endocrinology and Metabolism·A VermeulenJ M Kaufman
Feb 29, 2000·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H K GenantN Khaltaev
Oct 29, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·T M DavisI R Mackay
Feb 15, 2001·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·S HenzellR Prince
Mar 7, 2001·The Journal of Clinical Endocrinology and Metabolism·A V SchwartzUNKNOWN Study of Osteoporotic Features Research Group
Mar 7, 2001·The Journal of Clinical Endocrinology and Metabolism·P SzulcP D Delmas
Jun 26, 2001·Diabetes Care·K K NicodemusUNKNOWN Iowa Women's Health Study
Jun 26, 2001·Diabetes Care·R Q IversUNKNOWN Blue Mountains Eye Study
Oct 3, 2001·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M LuntJ Reeve
Oct 5, 2001·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·P J López-IbarraM A Diosdado
Apr 1, 2003·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Roger I PriceRichard L Prince
Apr 4, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D A HanleyUNKNOWN Canadian Multicentre Osteoporosis Study Research Group
Aug 9, 2003·Stroke; a Journal of Cerebral Circulation·Melissa GillettUNKNOWN Fremantle Diabetes Study

❮ Previous
Next ❯

Citations

May 11, 2010·Diabetologia·A P ChobotW Pluskiewicz
Oct 30, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·I R Reid
Dec 17, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M T SahaH H Saha
Mar 28, 2012·European Journal of Epidemiology·Lili MaFernando Rivadeneira
May 1, 2012·International Journal of Epidemiology·Timothy M E DavisWendy A Davis
Oct 2, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Laurentiu BadescuManuela Ciocoiu
Sep 26, 2008·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Miljanka VuksanovićBranka Zerajić
Mar 12, 2013·Journal of Aging Research·Ryan T CrewsStephanie C Wu
Apr 23, 2013·Journal of Osteoporosis·Ameya JoshiNikhil Bhagwat
May 27, 2014·Cell and Tissue Research·Juliana S CunhaMirian A Boim
Nov 6, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity·Elsa S Strotmeyer, Jane A Cauley
Jan 21, 2012·Current Opinion in Endocrinology, Diabetes, and Obesity·Kendall F Moseley
Mar 10, 2016·Journal of Diabetes and Its Complications·Rachel AgiusStephen Fava
Nov 6, 2015·European Journal of Endocrinology·Stephen HoughUNKNOWN IOF CSA Bone and Diabetes Working Group
Feb 11, 2012·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Senay ArikanDeniz Gokalp
Nov 11, 2011·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Elba BandeiraFrancisco Bandeira
Oct 19, 2010·Diabetes Research and Clinical Practice·Yijun ZhouHongwu Yang
Apr 17, 2008·Journal of Diabetes and Its Complications·Inan AnaforogluMelek Eda Ertorer
Jan 8, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·E J HamiltonT M E Davis
Jan 18, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·V RigalleauH Gin
Feb 13, 2013·International Journal of Endocrinology·Hai-Ling ChenJu-Fen Li
Jan 3, 2012·Physiotherapy Canada. Physiothérapie Canada·Erin GormanMaureen C Ashe
May 1, 2012·Ultrasound in Medicine & Biology·Agata P ChobotWojciech Pluskiewicz
Nov 7, 2012·Diabetes & Metabolism Journal·Kyung Soo KimSeok Won Park
Oct 6, 2016·Current Osteoporosis Reports·Hillary A Keenan, Ernesto Maddaloni
Feb 12, 2017·Dento Maxillo Facial Radiology·Luciana MunhozEmiko S Arita
May 8, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N Jiang, W Xia
Jul 23, 2018·The Journal of Clinical Endocrinology and Metabolism·Emma J HamiltonTimothy M E Davis
May 15, 2018·The Open Rheumatology Journal·Shaymaa Abdalwahed AbdulameerSyed Azhar Syed Sulaiman
May 14, 2019·Expert Opinion on Biological Therapy·Sahar MohsinErnest A Adeghate
Jan 13, 2016·The Journal of Clinical Endocrinology and Metabolism·Jakob Starup-LindePeter Vestergaard
Jul 28, 2020·Current Osteoporosis Reports·Kristen Jackson, Kendall F Moseley
Jun 6, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·V N ShahW M Kohrt
May 4, 2018·Clinical Diabetes and Endocrinology·Rodrigo J Valderrábano, Maria I Linares
Mar 1, 2015·Expert Review of Endocrinology & Metabolism·Naiemh AbdalrahmanSyed Faisal Ahmed
Jan 4, 2017·International Journal of Endocrinology·Giuseppina T RussoDomenico Cucinotta
Feb 25, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·U StumpfK Kostev
Oct 30, 2008·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·William W K To, Margaret W N Wong
Jul 12, 2017·Journal of Diabetes Research·Tânia A P FernandesJosé A A Brito
Dec 30, 2017·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Leon LenchikDonald W Bowden
Aug 12, 2018·Joint, Bone, Spine : Revue Du Rhumatisme·Bernard CortetJulien Paccou

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