Bone mineral density and the risk of breast cancer: a case-control study of Korean women

Annals of Epidemiology
Bo-Kyoung KimJohn L Hopper

Abstract

Bone mineral density (BMD) may be useful as a surrogate marker reflecting lifetime exposure to estrogen in a woman. Our study aimed to investigate an association between BMD and breast cancer risk. A case-control study was conducted using 253 breast cancer cases and 506 age and menopausal status-matched controls from the same institution. Cases were ascertained through medical record review of the women with abnormal mammographic findings. BMD was measured at the lumbar spine and femoral neck using a dual-energy X-ray absorptiometry. The association was estimated by conditional logistic regression analysis with an adjustment for covariates. Although there was no difference in the association between pre- and postmenopausal disease, the association between BMD and breast cancer was evident for postmenopausal breast cancer. One standard deviation in age and menopausal status adjusted BMD at lumbar spine and femur neck was associated with 1.35-fold (standard error = 0.19, P = .04) and 1.34-fold (standard error = 0.20, P = .05) increased likelihood of breast cancer risk, respectively, for postmenopausal women. After adjusting for covariates, higher BMD at lumbar spine and femur neck are associated with increased likelihood of breas...Continue Reading

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Citations

Oct 16, 2015·Cancer Causes & Control : CCC·Heidi MosesonIsabelle Romieu
Oct 3, 2015·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Jong-Myon Bae, Eun Hee Kim
Jan 18, 2018·Proceedings of the National Academy of Sciences of the United States of America·Claire-Sophie DevignesSylvain Provot
Jun 27, 2019·BioMed Research International·Larissa Vaz GonçalvesRuffo Freitas-Junior
Nov 20, 2016·Journal of Women's Health·Jong Min LeeAdetunji T Toriola

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