Bone mineral density and trabecular bone score in elderly type 2 diabetes Southeast Asian patients with severe osteoporotic hip fractures

PloS One
Linsey U GaniThomas F J King

Abstract

Studies show trabecular bone score (TBS) may provide information regarding bone quality independent of bone mineral density (BMD) in type 2 diabetes (DM2) patients. We analyzed our Southeast Asian severe osteoporotic hip fracture patients to study these differences. We conducted a retrospective cross-sectional analysis of subjects admitted to Changi General Hospital, Singapore with severe osteoporotic hip fractures from 2014-2017 who had BMD performed. Electronic records were reviewed and subjects were classified as having diabetes according to the WHO 2019 criteria. DM2 patients were classified according to their HbA1c into well controlled (HbA1c < 7%) and poorly controlled (HbA1c ≥ 7%) DM2. Elderly patients with hip fractures present with average femur neck T scores at the osteoporotic range, however those with DM2 had higher BMD and TBS values compared to non DM2 patients. These differences were statistically significant in elderly women-poorly controlled elderly DM2 women with hip fracture had the highest total hip T-score (-2.57 ± 0.86) vs (-2.76 ± 0.96) in well controlled DM2 and (-3.09 ± 1.01) in non DM2 women with hip fracture, p < 0.001. In contrast, TBS scores were lower in poorly controlled DM2 women with hip fractur...Continue Reading

References

Nov 1, 1992·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C CooperL J Melton
Nov 1, 1994·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A Kanis
Jul 1, 1995·Diabetes·J C KrakauerA M Parfitt
Apr 4, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D A HanleyUNKNOWN Canadian Multicentre Osteoporosis Study Research Group
Jun 9, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·I I de LiefdeH A P Pols
Oct 11, 2005·American Journal of Physiology. Endocrinology and Metabolism·Kathryn M ThrailkillJohn L Fowlkes
Jun 28, 2006·Diabetes Care·Mohsen JanghorbaniFrank Hu
Jun 29, 2006·The Journal of Clinical Endocrinology and Metabolism·Denise E BondsKaren L Margolis
Jun 19, 2007·American Journal of Epidemiology·Mohsen JanghorbaniFrank B Hu
Sep 18, 2008·The Journal of Clinical Endocrinology and Metabolism·L Joseph MeltonSundeep Khosla
May 28, 2009·JAMA : the Journal of the American Medical Association·Juliana C N ChanFrank B Hu
Jan 24, 2013·The Journal of Clinical Endocrinology and Metabolism·William D LeslieUNKNOWN Manitoba Bone Density Program
Mar 5, 2013·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·William D LeslieUNKNOWN Manitoba Bone Density Program
Mar 26, 2013·Diabetes Research and Clinical Practice·Hui ChenAnming Ni
May 18, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R DufourN Mehsen
Sep 11, 2014·Investigative Ophthalmology & Visual Science·Won June LeeHeeyoon Cho
Nov 5, 2014·The Journal of Clinical Endocrinology and Metabolism·Jung Hee KimChan Soo Shin
Nov 18, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Amy L EvansJennifer S Walsh
Jan 13, 2015·Bone·Anne C LookerSharon H Saydah
Nov 5, 2016·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Chanika SritaraPiyamitr Sritara
Aug 19, 2015·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Barbara C SilvaWilliam D Leslie
Oct 27, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Eugene V McCloskeyJohn A Kanis
Feb 14, 2016·BMJ Open·Jakob Starup-LindePeter Vestergaard
Oct 21, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lisa LangsetmoUNKNOWN Osteoporotic Fractures in Men (MrOS) Research Group
May 11, 2016·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Rajesh K JainTamara J Vokes
May 29, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E A C de WaardJ P W van den Bergh
Jul 25, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·G I SchacterD Hans
Oct 28, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K RuppertD H Solomon
Dec 22, 2017·Journal of Internal Medicine·J Compston
Apr 25, 2018·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Nahid RianonSusan Fisher-Hoch
Jan 8, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Gemma TatangeloKerrie M Sanders
Jul 22, 2019·Diabetes Research and Clinical Practice·Lan T Ho-PhamTuan V Nguyen

❮ Previous
Next ❯

Citations

Jun 27, 2021·BMC Musculoskeletal Disorders·Negar DelbariFaraneh Farsad

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
amputation

Software Mentioned

Statistical Package for Social Science ( SPSS
iNsight

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.