Bone mineral density assessment in children with inflammatory bowel disease

Gastroenterology
R GokhaleB S Kirschner

Abstract

Children with inflammatory bowel disease (IBD) are at risk for osteoporosis because of undernutrition, delayed puberty, and prolonged corticosteroid use. The aim of this study was to compare bone mineral density (BMD) in children with IBD with that in normal children and to assess the effects of nutritional and hormonal factors and corticosteroid dosages on BMD. One hundred sixty-two subjects (99 with IBD and 63 healthy sibling controls) were enrolled. Patients underwent anthropometric assessment, pubertal staging, bone age radiography, and BMD assessment by dual energy x-ray absorptiometry of the lumbar spine, femoral neck, and radius. Laboratory evaluations included serum calcium, phosphate, alkaline phosphatase, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, parathyroid hormone, osteocalcin, urinary N-telopeptides, albumin, insulin-like growth factor I, and testosterone or estradiol. Cumulative corticosteroid doses were calculated. BMD Z scores at the lumbar spine and femoral neck were lower in patients with IBD, and lower in those with Crohn's disease compared with those with ulcerative colitis. Low BMD persisted after correction for bone age in girls with Crohn's disease (lumbar spine, P = 0.004; femoral neck, P = 0.002). C...Continue Reading

Citations

Jan 9, 2007·Inflammatory Bowel Diseases·Francisco A SylvesterAnne M Griffiths
Jan 9, 2007·Inflammatory Bowel Diseases·Massimiliano PaganelliSalvatore Cucchiara
Feb 13, 2008·Inflammatory Bowel Diseases·Robert HeuschkelAnne Griffiths
Jul 29, 2009·Inflammatory Bowel Diseases·Susanne BechtoldSibylle Koletzko
Sep 28, 2010·Inflammatory Bowel Diseases·Michael D KappelmanRobert S Sandler
Apr 11, 2012·Inflammatory Bowel Diseases·Aaron R ProsnitzMeena Thayu
Dec 4, 1998·Inflammatory Bowel Diseases·D HerzogE G Seidman
Jun 26, 2012·Calcified Tissue International·Saila LaaksoOuti Mäkitie
Jan 1, 2008·Reviews in Endocrine & Metabolic Disorders·Anuradha Viswanathan, Francisco A Sylvester
May 8, 2003·Current Gastroenterology Reports·Manisha Harpavat, David J Keljo
Jul 17, 2003·Current Gastroenterology Reports·Carmen Cuffari, Gary R Lichtenstein
Sep 12, 2000·Current Gastroenterology Reports·D G Kelly
Mar 18, 1999·Baillière's Clinical Gastroenterology·O Goulet
Apr 5, 2003·Best Practice & Research. Clinical Gastroenterology·Ranjana Gokhale, Barbara S Kirschner
Aug 29, 2002·Alimentary Pharmacology & Therapeutics·R D Cohen
Oct 23, 2002·Alimentary Pharmacology & Therapeutics·E J LambA F Muller
Jun 10, 2000·Journal of Gastroenterology and Hepatology·S H LeeR Chang
Oct 7, 2006·Current Opinion in Gastroenterology·G Marx, E G Seidman
Jul 15, 2000·Journal of Pediatric Gastroenterology and Nutrition·R B HeuschkelA E Baird
Aug 21, 2002·Journal of Pediatric Gastroenterology and Nutrition·Arie LevineRaanan Shamir
Sep 28, 2002·Journal of Pediatric Gastroenterology and Nutrition·Marian D PfefferkornJean P Molleston
Jan 28, 2003·Journal of Pediatric Gastroenterology and Nutrition·Arie LevineUNKNOWN Israeli Pediatric Gastroenterology Association Budesonide Study Group
Mar 27, 2003·Journal of Pediatric Gastroenterology and Nutrition·Arie LevineJames Markowitz
Jun 10, 2004·Journal of Pediatric Gastroenterology and Nutrition·Ronald E KleinmanUNKNOWN North American Society for Pediatric Gastroenterology, Hepatology And Nutrition
May 14, 2005·Nuclear Medicine Communications·David E SimpsonAnthony J Coakley
Nov 11, 1999·Current Opinion in Pediatrics·F A Sylvester
Jun 20, 2002·European Journal of Gastroenterology & Hepatology·Juliet E Compston
Jun 20, 2002·European Journal of Gastroenterology & Hepatology·Nicole BregenzerTilo Andus
Aug 24, 1999·Inflammatory Bowel Diseases·E J SemeaoV A Stallings
Aug 24, 1999·Inflammatory Bowel Diseases·R M Issenman
Mar 27, 2003·Inflammatory Bowel Diseases·Johanna C EscherRichard J Grand
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·A BurkeJ L Rombeau
May 21, 2005·Inflammatory Bowel Diseases·Elizabeth HaitRichard Grand
Oct 22, 2005·Inflammatory Bowel Diseases·Francisco A Sylvester
Mar 8, 2005·Journal of Pediatric Gastroenterology and Nutrition·Manisha HarpavatDavid J Keljo
Mar 30, 2005·Journal of Pediatric Gastroenterology and Nutrition·Lori J StarkJames Heubi
Jul 5, 2006·Journal of Pediatric Gastroenterology and Nutrition·Frank WaltherAnnette Findeisen
Feb 28, 2008·Current Opinion in Gastroenterology·Helen M PappaRichard J Grand
Jun 23, 2011·Journal of Pediatric Gastroenterology and Nutrition·Helen PappaCatherine Gordon
Jan 10, 2002·Clinical Microbiology Reviews·Barbara A HendricksonJudy H Cho
Mar 29, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Francisco A SylvesterGloria A Gronowicz
Nov 3, 2006·Pediatrics·Helen M PappaRichard J Grand
Jul 6, 2014·PloS One·Lauren Elizabeth VeitBenjamin Udoka Nwosu

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