Bone mineral density changes among HIV-uninfected young adults in a randomised trial of pre-exposure prophylaxis with tenofovir-emtricitabine or placebo in Botswana

PloS One
Michael KasondeLynn A Paxton

Abstract

Tenofovir-emtricitabine (TDF-FTC) pre-exposure prophylaxis (PrEP) has been found to be effective for prevention of HIV infection in several clinical trials. Two studies of TDF PrEP among men who have sex with men showed slight bone mineral density (BMD) loss. We investigated the effect of TDF and the interaction of TDF and hormonal contraception on BMD among HIV-uninfected African men and women. We evaluated the effects on BMD of using daily oral TDF-FTC compared to placebo among heterosexual men and women aged 18-29 years enrolled in the Botswana TDF2 PrEP study. Participants had BMD measurements at baseline and thereafter at 6-month intervals with dual-energy X-ray absorptiometry (DXA) scans at the hip, spine, and forearm. A total of 220 participants (108 TDF-FTC, 112 placebo) had baseline DXA BMD measurements at three anatomic sites. Fifteen (6.8%) participants had low baseline BMD (z-score of <-2.0 at any anatomic site), including 3/114 women (2.6%) and 12/106 men (11.3%) (p = 0.02). Low baseline BMD was associated with being underweight (p = 0.02), having high blood urea nitrogen (p = 0.02) or high alkaline phosphatase (p = 0.03), and low creatinine clearance (p = 0.04). BMD losses of >3.0% at any anatomic site at any time...Continue Reading

Associated Clinical Trials

References

Jul 19, 1992·The New England Journal of Medicine·C C JohnstonM Peacock
Aug 18, 1993·JAMA : the Journal of the American Medical Association·T LloydH E Kulin
Apr 30, 1999·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·B A Cromer
May 4, 2004·Obstetrics and Gynecology·Abbey B BerensonAngelyn Thomas
Jul 14, 2004·JAMA : the Journal of the American Medical Association·Michael S SaagUNKNOWN FTC-301A Study Team
Jul 14, 2004·JAMA : the Journal of the American Medical Association·Joel E GallantUNKNOWN 903 Study Group
Jan 20, 2006·The New England Journal of Medicine·Joel E GallantUNKNOWN Study 934 Group
Feb 22, 2007·The Journal of Clinical Endocrinology and Metabolism·Peter NordströmAnna Nordström
Oct 17, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B Lawrence RiggsSundeep Khosla
Mar 7, 2009·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Serge PerrotClaire Le Jeunne
Oct 22, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Allison MartinAndrew Carr
Nov 26, 2010·The New England Journal of Medicine·Robert M GrantUNKNOWN iPrEx Study Team
Mar 2, 2011·PloS One·Julie A WomackUNKNOWN Veterans Aging Cohort Study Project Team
Jun 12, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S FerrariUNKNOWN IOF Committee of Scientific Advisors Working Group on Osteoporosis Pathophysiology
Jun 16, 2012·The Journal of Clinical Endocrinology and Metabolism·Eun Young LeeSung-Kil Lim
Jul 13, 2012·The New England Journal of Medicine·Jared M BaetenUNKNOWN Partners PrEP Study Team
Jul 13, 2012·The New England Journal of Medicine·Michael C ThigpenUNKNOWN TDF2 Study Group
Apr 29, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nicole C WrightBess Dawson-Hughes

❮ Previous
Next ❯

Citations

Dec 5, 2015·Expert Opinion on Drug Safety·Kenneth K Mugwanya, Jared M Baeten
Sep 29, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Marc M SolomonUNKNOWN iPrEx Study Team
Feb 13, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Brenda G MirembeUNKNOWN MTN-003B Protocol Team
Jan 23, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David V GliddenRobert M Grant
Feb 15, 2015·Archives of Osteoporosis·Nyaradzo M MgodiUNKNOWN MTN-003B Protocol Team
Apr 25, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kathleen MulliganUNKNOWN Preexposure Prophylaxis Initiative Study Team
Apr 25, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Julian Falutz
Apr 18, 2017·Current Treatment Options in Infectious Diseases·Caitlin A MoranIghovwerha Ofotokun
Jun 7, 2018·Alcoholism, Clinical and Experimental Research·Richard SaitzJeffrey H Samet
Mar 15, 2019·HIV Medicine·Michael BradyIngrid Young
May 23, 2019·AIDS Research and Human Retroviruses·Julie J Kim-ChangUNKNOWN Adolescent Medicine Trials Network for HIV/AIDS Interventions
Apr 4, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Matthew M HamillAnn Prentice
Jun 24, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·David V GliddenRobert M Grant
Oct 30, 2019·Antimicrobial Agents and Chemotherapy·Sigcinile DlaminiJanet P Hapgood
Jan 9, 2020·Journal of the International AIDS Society·Dvora L Joseph DaveyUNKNOWN PrEP in Pregnancy Working Group
Feb 10, 2016·Current Opinion in HIV and AIDS·Philip M Grant, Aoife G Cotter
Nov 1, 2016·The Pediatric Infectious Disease Journal·Luiz Eduardo OsorioUNKNOWN HIV Prevention Trials Network (HPTN) 057 Protocol Team
Apr 24, 2020·MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports·Mary R TannerDawn K Smith
Sep 30, 2016·Infectious Diseases and Therapy·Olubanke DaviesJulie Fox
Jun 12, 2019·JAMA : the Journal of the American Medical Association·UNKNOWN US Preventive Services Task ForceJohn B Wong
Aug 17, 2020·Clinical Rheumatology·F ParukA A Kalla
Jun 3, 2015·Infectious Diseases and Therapy·Andrew Ustianowski, Joop E Arends
May 2, 2015·Current Treatment Options in Infectious Diseases·Susanne Doblecki-LewisAlbert Liu
Oct 12, 2020·Journal of the International AIDS Society·Krittaporn PornpaisalsakulUNKNOWN CE-PID - IHRI Adolescent Study Team
Feb 12, 2021·Infectious Diseases and Therapy·Sheldon D Fields, Elyse Tung

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
contraception

Clinical Trials Mentioned

NCT00448669

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.