Bone mineral density changes in pregnancies with gestational hypertension: a longitudinal study using quantitative ultrasound measurements.

Archives of Gynecology and Obstetrics
William W K To, Margaret W N Wong

Abstract

To compare the maternal bone mineral density (BMD) changes in gestational hypertensive and normotensive pregnancies using quantitative ultrasound. Consecutive patients were recruited from a general obstetric clinic over a period of 9 months. BMD measurements were performed at the os calcis in early pregnancy before 20 weeks and in the late third trimester after 36 weeks, using a Hologic Sahara Clinical Bone Sonometer system. These patients were followed up in accordance with standard antenatal protocol. The diagnosis of gestational hypertension (GH) was made based on a standard institutional protocol. The changes in BMD from early to late pregnancy were compared between those with/without GH. A total of 450 patients with complete data were analyzed. The overall incidence of GH was 4.8% (n = 22), of which 1.7% (n = 8) fulfilled the definitions of severe pre-eclampsia. A mean BMD loss of 0.0382 g/cm2 (around 6% of early pregnancy BMD) [corrected] was demonstrable from early to late gestation The hypertensive group has marginally higher mean BMD loss as compared to the normotensive group (0.052 vs. 0.037 g/cm²; P = 0.037). However, regression analysis models showed that early pregnancy BMD values, early pregnancy fat percentage an...Continue Reading

References

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Feb 6, 2010·Archives of Gynecology and Obstetrics·Thorkild F Nielsen, Ragnar Rylander

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Citations

Feb 27, 2014·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Julia WildHarald Zeisler
Dec 1, 2017·Climacteric : the Journal of the International Menopause Society·J P BeckmanD R Holmes
Feb 12, 2017·Current Osteoporosis Reports·Chantal M J de BakkerX Sherry Liu
Jul 30, 2020·International Journal of Molecular Sciences·Ana Correia-BrancoMary C Wallingford

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