Bone mineral density in children with asthma receiving long-term treatment with inhaled budesonide

American Journal of Respiratory and Critical Care Medicine
L Agertoft, S Pedersen

Abstract

The aim of our study was to assess the effects of long-term treatment with inhaled budesonide (BUD) on total body bone mineral density (BMD), total body bone mineral capacity (BMC), total bone calcium (TBC), and body composition in children with asthma. Dual energy X-ray absorptiometry (DEXA scan) was performed in 157 asthmatic children treated with inhaled BUD at a mean daily dose of 504 microg (range, 189 to 1,322 microg) for 3 to 6 yr (mean, 4.5 yr). Measurements were compared with those of 111 age-matched children also suffering from asthma but who had never been treated with exogenous corticosteroids for more than 14 d (control group). There were no statistically significant differences between the two groups in BMD (BUD = 0.915 g/cm2, controls = 0.917 g/cm2), BMC (BUD = 1,378 g, controls = 1,367 g), TBC (BUD = 524 g, controls = 519 g), or body composition (lean body weight = 27,600 g [BUD] and 26,923 g [control], % body fat = 20.1% [BUD] and 20.3% [control]). Furthermore, there was no correlation between any of these parameters and duration of treatment, accumulated or current dose of budesonide. Three to six years of treatment with inhaled budesonide at an average daily dose of 504 microg has no adverse effect on total B...Continue Reading

References

Mar 1, 1977·The Journal of Allergy and Clinical Immunology·R HauspieF Alexander
Sep 1, 1992·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·F A TylavskyT N Taft
Nov 1, 1992·The Journal of Allergy and Clinical Immunology·R SorvaA Sorva
Jul 19, 1992·The New England Journal of Medicine·C C JohnstonM Peacock
Nov 11, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C W SlemendaC C Johnston
Apr 1, 1989·Scandinavian Journal of Clinical and Laboratory Investigation·A GotfredsenC Christiansen
Nov 1, 1986·Archives of Disease in Childhood·L Balfour-Lynn
Sep 1, 1987·Annals of Internal Medicine·N A PocockN L Huq
Jun 1, 1969·Archives of Disease in Childhood·W A Marshall, J M Tanner
Aug 4, 1983·The New England Journal of Medicine·A D Adinoff, J R Hollister
May 1, 1982·The Journal of Allergy and Clinical Immunology·A C FergusonW J Tze
Sep 1, 1981·Acta paediatrica Scandinavica·A J MartinP D Phelan
Aug 1, 1995·Calcified Tissue International·K MichaëlssonS Ljunghall
Aug 1, 1995·The Journal of Allergy and Clinical Immunology·J H ToogoodD Drost
Sep 1, 1994·The Journal of Allergy and Clinical Immunology·K A KinbergJ C Gallagher
Oct 1, 1993·The American Review of Respiratory Disease·P J Barnes, S Pedersen
Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·L C MartinatiA L Boner
Sep 1, 1995·Pediatric Pulmonology·R J HoppG C Gallagher

❮ Previous
Next ❯

Citations

Feb 12, 2002·Pediatric Pulmonology·David B Allen
Nov 9, 2004·Pediatric Pulmonology·Edward J O'Connell
Apr 14, 2007·Pediatric Radiology·Larry A BinkovitzMaria J Henwood
Jul 3, 2008·Pediatric Radiology·Larry A BinkovitzPaul Sparke
Feb 18, 2011·Journal of Bone and Mineral Metabolism·Ozkaya EminSamanci Nedim
Nov 18, 1998·The Journal of Allergy and Clinical Immunology·F E Simons
Dec 4, 2003·Clinical Therapeutics·Edward J O'Connell
Dec 4, 2003·Clinical Therapeutics·David E Skoner
Dec 4, 2003·Clinical Therapeutics·David S Pearlman
Jul 30, 2004·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Stanley J SzeflerMario Cruz-Rivera
Jun 29, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·G G ShapiroD S Pearlman
Jan 11, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·S B BonalaA T Schneider
Mar 4, 2000·Allergy·G PassalacquaH J Malling
Oct 7, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P König, C F Grigg
Oct 12, 2000·The New England Journal of Medicine·L Agertoft, S Pedersen
Nov 11, 1999·Current Opinion in Pediatrics·L C Schneider, M R Lester
May 17, 2000·Current Opinion in Pulmonary Medicine·B E Chipps, D R Chipps
Dec 26, 2001·Current Opinion in Pulmonary Medicine·Conroy A WongPaul M Casey
Jul 27, 2004·Current Opinion in Pediatrics·David B Allen
Jul 16, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Tae-Wan KimYou-Young Kim
Jul 26, 2002·Archives of Disease in Childhood·T Mushtaq, S F Ahmed
Dec 19, 2001·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·P GeusensS van der Linden
Jan 22, 2011·Pulmonary Pharmacology & Therapeutics·Iwona StelmachPawel Majak
Feb 5, 1999·The Journal of Pediatrics·P L Brand, R J Roorda
Jun 5, 2007·Seminars in Nuclear Medicine·Larry A BinkovitzPaul Sparke
Dec 22, 2004·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Vagn Braendholt JensenPalle Prahl
May 29, 2003·Pediatric Pulmonology·Stanley Szefler, Søren Pedersen
Aug 1, 2007·Expert Review of Respiratory Medicine·David B Allen
Aug 9, 2005·Endocrinology and Metabolism Clinics of North America·David B Allen
Jan 21, 2003·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·Benay JohnsonJane Andersen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.