PMID: 15338684Sep 2, 2004Paper

Bone mineral density in live related kidney transplant children and adolescents

International Urology and Nephrology
Amr A el-HusseiniMohamed A Ghoneim

Abstract

Successful kidney transplantation corrects many of the metabolic abnormalities associated with development of renal osteodystrophy, but despite a well-functioning graft, osteopenia, remains prevalent in adult and pediatric kidney recipients. The factors that affect the bone mineral density (BMD) and the long term course of BMD after transplantation in children is still unknown. We performed a cross sectional study to determine BMD in 83 recipients who received living renal allotransplants in Mansoura Urology & Nephrology Center between 1981 and 2002 (mean age at transplantation 13.2 +/- 3.1 years) by dual energy x-ray absorptiometry at various time intervals up to 16 years after transplantation (mean duration after transplantation was 48 +/- 34 months, range 12-192 months). The mean +/- SD for BMD was -2.28 +/- 2.06 for lumbar 2-4 spine and -1.44 +/- 1.44 for the total body BMD as corrected for body surface area. Osteopenia/osteoporosis were present in about two thirds of our kidney transplant recipients. The significant risk factors for osteopenia/osteoprosis using univariate analysis were the cyclosporine based immunosuppressive regimen, cumulative dose of steroids/m2 surface area, graft dysfunction and the urinary deoxypyrid...Continue Reading

Citations

Apr 30, 2008·Rheumatology International·Alia M AtallahMohamed A Ghoneim
Apr 19, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J W Groothoff
Aug 28, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Alessandro MussaRosanna Coppo
Mar 25, 2011·Pediatric Transplantation·Ali DerakhshanGhamar H Al-Hashemi
Sep 17, 2013·Clinical Transplantation·Athanasios ChristoforidisFotios Papachristou
Jul 5, 2006·Seminars in Pediatric Surgery·Gina S Sucato, Pamela J Murray
Mar 31, 2015·Pediatric Transplantation·Bahar BüyükkaragözEnver Hasanoglu
Jul 29, 2005·Pediatric Transplantation·Damla GökşenCaner Kabasakal
May 18, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ángela DelucchiLuis Michea

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